SYT15_HUMAN » Synaptotagmin-15

SYT15_HUMAN » Synaptotagmin-15
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SYT15_HUMAN » Synaptotagmin-15 » Chr10Syt;Synaptotagmin XV;SytXV;
Hydrophobic Thickness 35.2 ± 3.0 Å
Tilt Angle 1 ± 1°
ΔGtransfer -30.3 kcal/mol
ΔGfold -16.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 2-33 (2-36)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 162-268, PDBID: 1DQV, Subunit A, Seq Identity:43%, C2 domain

AA: 293-401, PDBID: 1K5W, Subunit A, Seq Identity:34%, C2 domain

UniProt annotation for SYT15_HUMAN » Synaptotagmin-15
FUNCTION: May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues.

SUBUNIT: Homodimer.

DOMAIN: Neither C2 domains mediates Ca(2+)-dependent or -independent phospholipid binding.

UniProt features for SYT15_HUMAN » Synaptotagmin-15
CHAIN 1 421 Synaptotagmin-15.
DOMAIN 149 248 C2 1.
DOMAIN 280 383 C2 2.
Amino Acid Sequence for SYT15_HUMAN » Synaptotagmin-15
MAEQLALVIG GTIGGLLLLL LIGASCCLWR RFCATLTYEE LPGTPAMATT AASSGQRDRP CQPHARTQLS RPPAVPFVVP PTLQGRDWVP LHSGEWADAP WDPCPASELL PHTSSGGLGD ACMVGAINPE LYKFPEDKSE TDFPDGCLGR LWFSVEYEQE AERLLVGLIK AQHLQAPSET CSPLVKLYLL PDERRFLQSK TKRKTSNPQF DEHFIFQVSS KTITQRVLKF SVYHVDRQRK HQLLGQVLFP LKNETLVGDC RRVIWRDLEA ESLEPPSEFG DLQFCLSYND YLSRLTVVVL RAKGLRLQDD RGIVSVFVKV SLMNHNKFVK CKKTSAVLGS INPVYNETFS FKADATELDT ASLSLTVVQN MEGDKSQQLG RVVVGPYMYT RGRELEHWDE MLSKPKELVK RWHALCRTTE P