SYT14_HUMAN » Synaptotagmin-14

SYT14_HUMAN » Synaptotagmin-14
Magnify SYT14_HUMAN » Synaptotagmin-14Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
SYT14_HUMAN » Synaptotagmin-14 » Synaptotagmin XIV;SytXIV;
Hydrophobic Thickness 30.0 ± 2.0 Å
Tilt Angle 2 ± 1°
ΔGtransfer -46.9 kcal/mol
ΔGfold -20.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 25-46 (23-48)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 275-379, PDBID: 1UGK, Subunit A, Seq Identity:27%, C2 domain

AA: 430-538, PDBID: 1DQV, Subunit A, Seq Identity:31%, C2 domain

UniProt annotation for SYT14_HUMAN » Synaptotagmin-14
FUNCTION: May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.

SUBUNIT: Homodimer. Can also form heterodimers (By similarity).

TISSUE SPECIFICITY: Highly expressed in fetal and adult brain tissue.

DISEASE: Spinocerebellar ataxia, autosomal recessive, 11 (SCAR11) OMIM: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR11 is associated with psychomotor retardation. caused by mutations affecting the gene represented in this entry.

UniProt features for SYT14_HUMAN » Synaptotagmin-14
CHAIN 1 555 Synaptotagmin-14.
DOMAIN 276 378 C2 1.
DOMAIN 417 521 C2 2.
Amino Acid Sequence for SYT14_HUMAN » Synaptotagmin-14
MAIEGGERTC GVHELICIRK VSPEAVGFLS AVGVFIILML LLFLYINKKF CFENVGGFPD LGSEYSTRKN SQDKIYNSYM DKDEHGSSSE SEDEALGKYH EALSRTHNSR LPLADSRQRN YAWETRQKYS PLSAEYDGYS SEASIDEGNC IQRMRRTPPL DELQPPPYQD DSGSPHLSCT PSEIGDSKCE FSHCSNSPRC SYNKCPSEGS TGHEIESFHN KGYEEDVPSD STAVLSPEDM SAQGSSSQLP KPFDPEPEAK YGTLDVTFDY DSQEQKLLVT VTAVTDIPTY NRTGGNSWQV HLVLLPIKKQ RAKTSIQRGP CPVFTETFKF NHVESEMIGN YAVRFRLYGV HRMKKEKIVG EKIFYLTKLN LQGKMSLPVI LEPSYNHSGC DSQMSVSEMS CSESTSSCQS LEHGSVPEIL IGLLYNATTG RLSAEVIKGS HFKNLAANRP PNTYVKLTLL NSMGQEMSKC KTSIRRGQPN PVYKETFVFQ VALFQLSDVT LILSVYNKRS MKRKEMIGWI SLGLNSSGEE ELNHWTEMKE SKGQQVCRWH ALLES