SYT13_HUMAN » Synaptotagmin-13

SYT13_HUMAN » Synaptotagmin-13
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Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
SYT13_HUMAN » Synaptotagmin-13 » Synaptotagmin XIII;SytXIII;
Hydrophobic Thickness 31.6 ± 2.0 Å
Tilt Angle 44 ± 0°
ΔGtransfer -16.7 kcal/mol
ΔGfold -10.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 5-30 (5-33)
Pathways none
PDB 1wfm (155-279)
OPM 1wfm
Complexes none
Interactions

NRX1A, Complex: SYT13:NRX1A

Domains

AA: 171-277, PDBID: 1WFM, Subunit A, Seq Identity:100%, C2 domain

AA: 302-410, PDBID: 1K5W, Subunit A, Seq Identity:37%, C2 domain

UniProt annotation for SYT13_HUMAN » Synaptotagmin-13
FUNCTION: May be involved in transport vesicle docking to the plasma membrane.

SUBUNIT: Interacts with NRXN1.

TISSUE SPECIFICITY: Expressed in brain, pancreas and kidney.

DOMAIN: The first C2 domain/C2A does not mediate Ca(2+)-dependent phospholipid binding.

DOMAIN: The second C2 domain/C2B domain binds phospholipids regardless of whether calcium is present.

UniProt features for SYT13_HUMAN » Synaptotagmin-13
CHAIN 1 426 Synaptotagmin-13.
DOMAIN 175 259 C2 1.
DOMAIN 289 394 C2 2.
Amino Acid Sequence for SYT13_HUMAN » Synaptotagmin-13
MVLSVPVIAL GATLGTATSI LALCGVTCLC RHMHPKKGLL PRDQDPDLEK AKPSLLGSAQ QFNVKKSTEP VQPRALLKFP DIYGPRPAVT APEVINYADY SLRSTEEPTA PASPQPPNDS RLKRQVTEEL FILPQNGVVE DVCVMETWNP EKAASWNQAP KLHYCLDYDC QKAELFVTRL EAVTSNHDGG CDCYVQGSVA NRTGSVEAQT ALKKRQLHTT WEEGLVLPLA EEELPTATLT LTLRTCDRFS RHSVAGELRL GLDGTSVPLG AAQWGELKTS AKEPSAGAGE VLLSISYLPA ANRLLVVLIK AKNLHSNQSK ELLGKDVSVK VTLKHQARKL KKKQTKRAKH KINPVWNEMI MFELPDDLLQ ASSVELEVLG QDDSGQSCAL GHCSLGLHTS GSERSHWEEM LKNPRRQIAM WHQLHL