SYT12_HUMAN » Synaptotagmin-12

SYT12_HUMAN » Synaptotagmin-12
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Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
SYT12_HUMAN » Synaptotagmin-12 » Synaptotagmin XII;SytXII;
Hydrophobic Thickness 29.6 ± 4.8 Å
Tilt Angle 30 ± 16°
ΔGtransfer -17.3 kcal/mol
ΔGfold -13.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 22-44 (19-46)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 167-274, PDBID: 1DQV, Subunit A, Seq Identity:23%, C2 domain

AA: 298-404, PDBID: 1W15, Subunit A, Seq Identity:40%, C2 domain

UniProt annotation for SYT12_HUMAN » Synaptotagmin-12
FUNCTION: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

SUBUNIT: Homodimer. Can also form heterodimers (By similarity).

UniProt features for SYT12_HUMAN » Synaptotagmin-12
CHAIN 1 421 Synaptotagmin-12.
DOMAIN 168 272 C2 1.
DOMAIN 285 388 C2 2.
Amino Acid Sequence for SYT12_HUMAN » Synaptotagmin-12
MAVDVAEYHL SVIKSPPGWE VGVYAAGALA LLGIAAVSLW KLWTSGSFPS PSPFPNYDYR YLQQKYGESC AEAREKRVPA WNAQRASTRG PPSRKGSLSI EDTFESISEL GPLELMGREL DLAPYGTLRK SQSADSLNSI SSVSNTFGQD FTLGQVEVSM EYDTASHTLN VAVMQGKDLL EREEASFESC FMRVSLLPDE QIVGISRIQR NAYSIFFDEK FSIPLDPTAL EEKSLRFSVF GIDEDERNVS TGVVELKLSV LDLPLQPFSG WLYLQDQNKA ADAVGEILLS LSYLPTAERL TVVVVKAKNL IWTNDKTTAD PFVKVYLLQD GRKMSKKKTA VKRDDPNPVF NEAMIFSVPA IVLQDLSLRV TVAESSSDGR GDNVGHVIIG PSASGMGTTH WNQMLATLRR PVSMWHAVRR N