SYT11_HUMAN » Synaptotagmin-11

SYT11_HUMAN » Synaptotagmin-11
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Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
SYT11_HUMAN » Synaptotagmin-11 » Synaptotagmin XI;SytXI;
Hydrophobic Thickness 34.8 ± 3.4 Å
Tilt Angle 13 ± 13°
ΔGtransfer -16.4 kcal/mol
ΔGfold -11.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 15-36 (15-46)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 172-279, PDBID: 1UGK, Subunit A, Seq Identity:71%, C2 domain

AA: 306-414, PDBID: 1W15, Subunit A, Seq Identity:60%, C2 domain

UniProt annotation for SYT11_HUMAN » Synaptotagmin-11
FUNCTION: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

SUBUNIT: Homodimer. Can also form heterodimers (By similarity). Interacts with PARK2.

UniProt features for SYT11_HUMAN » Synaptotagmin-11
CHAIN 1 431 Synaptotagmin-11.
DOMAIN 174 262 C2 1.
DOMAIN 304 397 C2 2.
Amino Acid Sequence for SYT11_HUMAN » Synaptotagmin-11
MAEITNIRPS FDVSPVVAGL IGASVLVVCV SVTVFVWSCC HQQAEKKQKN PPYKFIHMLK GISIYPETLS NKKKIIKVRR DKDGPGREGG RRNLLVDAAE AGLLSRDKDP RGPSSGSCID QLPIKMDYGE ELRSPITSLT PGESKTTSPS SPEEDVMLGS LTFSVDYNFP KKALVVTIQE AHGLPVMDDQ TQGSDPYIKM TILPDKRHRV KTRVLRKTLD PVFDETFTFY GIPYSQLQDL VLHFLVLSFD RFSRDDVIGE VMVPLAGVDP STGKVQLTRD IIKRNIQKCI SRGELQVSLS YQPVAQRMTV VVLKARHLPK MDITGLSGNP YVKVNVYYGR KRIAKKKTHV KKCTLNPIFN ESFIYDIPTD LLPDISIEFL VIDFDRTTKN EVVGRLILGA HSVTASGAEH WREVCESPRK PVAKWHSLSE Y