SYT10_HUMAN » Synaptotagmin-10

SYT10_HUMAN » Synaptotagmin-10
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Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
SYT10_HUMAN » Synaptotagmin-10 » Synaptotagmin X;SytX;
Hydrophobic Thickness 40.4 ± 1.8 Å
Tilt Angle 0 ± 2°
ΔGtransfer -38.8 kcal/mol
ΔGfold -21.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 52-79 (49-79)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 246-354, PDBID: 1DQV, Subunit A, Seq Identity:66%, C2 domain

AA: 378-498, PDBID: 1DQV, Subunit A, Seq Identity:52%, C2 domain

UniProt annotation for SYT10_HUMAN » Synaptotagmin-10
FUNCTION: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

SUBUNIT: Homodimer. Can also form heterodimers with SYT6 (By similarity).

TISSUE SPECIFICITY: Expressed only in pancreas, lung and kidney.

UniProt features for SYT10_HUMAN » Synaptotagmin-10
CHAIN 1 523 Synaptotagmin-10.
DOMAIN 233 334 C2 1.
DOMAIN 365 468 C2 2.
Amino Acid Sequence for SYT10_HUMAN » Synaptotagmin-10
MSFHKEDGVN SLCQKALHIV TELCFAGQVE WEKCSGIFPR DRGSQGGSST DISVSLLAVV VSFCGLALLV VSLFVFWKLC WPCWKSKPVT SNITTLPQSI SSAPTEVFET EEKKEIKENE KPAVKAIEPA IKISHTSPDI PAEVQTALKE HLIKHARVQR QITEPTSSTR HSSFRRHLPR QMQVSSVDFS MGTEPVLQRG ETTTSIGRIK PELYKQKSVD SEGNQNEDVK ICGKLNFTLQ YDYENELLVV KIIKALDLPA KDFTGTSDPY VKMYLLPDRK KKFQTRVHRK TLNPLFDETF QFPVAYDQLS NRKLHFSVYD FDRFSRHDMI GEVILDNLFE VSDLSREATV WKDIHCATTE SIDLGEIMFS LCYLPTAGRM TLTVIKCRNL KAMDITGSSD PYVKVSLMCE GRRLKKRKTT TKKNTLNPVY NEAIIFDIPP ENVDQVSLSI AVMDYDRVGH NEVIGVCRTG LDAEGLGRDH WNEMLAYHRK PITHWHPLLE LPGRATSFDS QGSCPSPKPP STP