SYBU_HUMAN » Syntabulin

SYBU_HUMAN » Syntabulin
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Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
SYBU_HUMAN » Syntabulin » Golgi-localized syntaphilin-related protein;Syntaxin-1-binding protein;
Hydrophobic Thickness 33.4 ± 2.5 Å
Tilt Angle 3 ± 2°
ΔGtransfer -24.5 kcal/mol
ΔGfold -8.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 606-628 (604-630)
Pathways none
PDB none
OPM none
Complexes none
Interactions

STX1A, Complex: STX1A:KINH:SYBU, PubMed

Domains

AA: 211-507, Golgi-localised syntaxin-1-binding clamp

UniProt annotation for SYBU_HUMAN » Syntabulin
FUNCTION: Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development.

SUBUNIT: Interacts with STX1A and KIF5B.

TISSUE SPECIFICITY: Isoform 3, isoform 4 and isoform 5 are expressed in HeLa cell line (at protein level). Isoform 3 is expressed in fetal and adult brain. Isoform 4 is expressed in numerous fetal tissues (brain, kidney, liver, lung, and thymus) and in adult brain, kidney, liver, lung, pancreas, colon, prostate, small intestine, testis and thymus. Isoform 5 is expressed in fetal brain, brain and small intestine.

UniProt features for SYBU_HUMAN » Syntabulin
CHAIN 1 663 Syntabulin.
REGION 2 417 Sufficient for interaction with KIF5B.
REGION 310 417 Sufficient for interaction with STX1A.
COILED 271 353 Potential.
Amino Acid Sequence for SYBU_HUMAN » Syntabulin
MGPLRESKKE HRVQHHDKEI SRSRIPRLIL RPHMPQQQHK VSPASESPFS EEESREFNPS SSGRSARTVS SNSFCSDDTG CPSSQSVSPV KTPSDAGNSP IGFCPGSDEG FTRKKCTIGM VGEGSIQSSR YKKESKSGLV KPGSEADFSS SSSTGSISAP EVHMSTAGSK RSSSSRNRGP HGRSNGASSH KPGSSPSSPR EKDLLSMLCR NQLSPVNIHP SYAPSSPSSS NSGSYKGSDC SPIMRRSGRY MSCGENHGVR PPNPEQYLTP LQQKEVTVRH LKTKLKESER RLHERESEIV ELKSQLARMR EDWIEEECHR VEAQLALKEA RKEIKQLKQV IETMRSSLAD KDKGIQKYFV DINIQNKKLE SLLQSMEMAH SGSLRDELCL DFPCDSPEKS LTLNPPLDTM ADGLSLEEQV TGEGADRELL VGDSIANSTD LFDEIVTATT TESGDLELVH STPGANVLEL LPIVMGQEEG SVVVERAVQT DVVPYSPAIS ELIQSVLQKL QDPCPSSLAS PDESEPDSME SFPESLSALV VDLTPRNPNS AILLSPVETP YANVDAEVHA NRLMRELDFA ACVEERLDGV IPLARGGVVR QYWSSSFLVD LLAVAAPVVP TVLWAFSTQR GGTDPVYNIG ALLRGCCVVA LHSLRRTAFR IKT