SUSD2_HUMAN » Sushi domain-containing protein 2

SUSD2_HUMAN » Sushi domain-containing protein 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SUSD2_HUMAN » Sushi domain-containing protein 2 »
Hydrophobic Thickness 35.6 ± 3.2 Å
Tilt Angle 18 ± 7°
ΔGtransfer -27.3 kcal/mol
ΔGfold -24.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 784-808 (784-812)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 29-64, PDBID: 2CQW, Subunit A, Seq Identity:76%, Somatomedin B domain

AA: 289-431, AMOP domain

AA: 447-613, von Willebrand factor type D domain

AA: 725-778, PDBID: 2YBY, Subunit A, Seq Identity:43%, Sushi repeat (SCR repeat)

UniProt annotation for SUSD2_HUMAN » Sushi domain-containing protein 2
FUNCTION: May be a cytokine receptor for C10ORF99. May be a tumor suppressor; together with C10ORF99 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed). May play a role in breast tumorigenesis (PubMed).

SUBUNIT: Interacts with LGALS1; leads to an increased amount of LGALS1 on the cell surface (PubMed). Interacts with C10ORF99; the interaction is direct (PubMed).

TISSUE SPECIFICITY: Highly expressed in breast cancer, but shows a restricted expression pattern in normal tissues such as adipose, adrenal gland, kidney, lung, mammary gland, placenta, thyroid, trachea, and uterus (PubMed). Also expressed in colon; down-regulated in colon cancer tisues (PubMed).

UniProt features for SUSD2_HUMAN » Sushi domain-containing protein 2
SIGNAL 1 27 Potential.
CHAIN 28 822 Sushi domain-containing protein 2.
DOMAIN 28 66 SMB.
DOMAIN 285 433 AMOP.
DOMAIN 446 667 VWFD.
DOMAIN 723 780 Sushi.
DISULFID 31 44 Alternate (By similarity).
DISULFID 31 35 By similarity.
DISULFID 35 62 Alternate (By similarity).
DISULFID 42 55 Alternate (By similarity).
DISULFID 42 44 By similarity.
DISULFID 48 54 By similarity.
DISULFID 55 62 By similarity.
DISULFID 725 765 By similarity.
DISULFID 751 778 By similarity.
Amino Acid Sequence for SUSD2_HUMAN » Sushi domain-containing protein 2
MKPALLPWAL LLLATALGPG PGPTADAQES CSMRCGALDG PCSCHPTCSG LGTCCLDFRD FCLEILPYSG SMMGGKDFVV RHFKMSSPTD ASVICRFKDS IQTLGHVDSS GQVHCVSPLL YESGRIPFTV SLDNGHSFPR AGTWLAVHPN KVSMMEKSEL VNETRWQYYG TANTSGNLSL TWHVKSLPTQ TITIELWGYE ETGMPYSQEW TAKWSYLYPL ATHIPNSGSF TFTPKPAPPS YQRWRVGALR IIDSKNYAGQ KDVQALWTND HALAWHLSDD FREDPVAWAR TQCQAWEELE DQLPNFLEEL PDCPCTLTQA RADSGRFFTD YGCDMEQGSV CTYHPGAVHC VRSVQASLRY GSGQQCCYTA DGTQLLTADS SGGSTPDRGH DWGAPPFRTP PRVPSMSHWL YDVLSFYYCC LWAPDCPRYM QRRPSNDCRN YRPPRLASAF GDPHFVTFDG TNFTFNGRGE YVLLEAALTD LRVQARAQPG TMSNGTETRG TGLTAVAVQE GNSDVVEVRL ANRTGGLEVL LNQEVLSFTE QSWMDLKGMF LSVAAGDRVS IMLASGAGLE VSVQGPFLSV SVLLPEKFLT HTHGLLGTLN NDPTDDFTLH SGRVLPPGTS PQELFLFGAN WTVHNASSLL TYDSWFLVHN FLYQPKHDPT FEPLFPSETT LNPSLAQEAA KLCGDDHFCN FDVAATGSLS TGTATRVAHQ LHQRRMQSLQ PVVSCGWLAP PPNGQKEGNR YLAGSTIYFH CDNGYSLAGA ETSTCQADGT WSSPTPKCQP GRSYAVLLGI IFGGLAVVAA VALVYVLLRR RKGNTHVWGA QP