SUN2_HUMAN » SUN domain-containing protein 2

SUN2_HUMAN » SUN domain-containing protein 2
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Topology in Nuclear inner membrane
Topologyintermembrane space
nucleus matrix side
SUN2_HUMAN » SUN domain-containing protein 2 » Protein unc-84 homolog B;Rab5-interacting protein;Rab5IP; Sad1/unc-84 protein-like 2;
Hydrophobic Thickness 33.2 ± 2.6 Å
Tilt Angle 18 ± 6°
ΔGtransfer -24.6 kcal/mol
ΔGfold -14.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology In
TM Segments 210-234 (207-234)
Pathways

Cell Cycle (Reactome)

Meiosis (Reactome)

PDB 3unp (A=520-717), 4dxr (A=522-717), 4dxs (A=522-717), 4dxt (A=522-717), 4fi9 (A=523-717)
OPM 3unp
Complexes

SYNE2:SUN2_HUMAN

Interactions

EMD, Complex: SUN2:EMD, PubMed

SYNE1, Complex: SUN2:SYNE1, PubMed

SYNE2, Complex: SUN2:SYNE2, PDBID: 4dxs, PubMed

Domains

AA: 581-715, PDBID: 3UNP, Subunit A, Seq Identity:100%, Sad1 / UNC-like C-terminal

UniProt annotation for SUN2_HUMAN » SUN domain-containing protein 2
FUNCTION: Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.

SUBUNIT: Core component of the LINC complex which is composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins. SUN domain-containing proteins interact with A-type lamins of the nuclear lamina, while at the other end of the complex, nesprins interact with unique cytoskeletal components. Interacts with SYNE1, SYNE2 and SYNE3. Interacts with A-type lamin. Interaction with lamins B1 and C is hardly detectable (By similarity). Interacts with EMD and RAB5A. Interacts with TMEM43.

TISSUE SPECIFICITY: Widely expressed. Highly expressed in heart, lung and muscle. Weakly expressed in fetal heart. Slightly overexpressed in some heart tissues form patients with congenital heart defects.

DOMAIN: The SUN domain may play a role in the nuclear anchoring and/or migration.

UniProt features for SUN2_HUMAN » SUN domain-containing protein 2
CHAIN 1 717 SUN domain-containing protein 2.
DOMAIN 555 716 SUN.
REGION 1 139 LMNA-binding (By similarity).
COILED 273 296 Potential.
COILED 348 440 Potential.
COILED 475 506 Potential.
Amino Acid Sequence for SUN2_HUMAN » SUN domain-containing protein 2
MSRRSQRLTR YSQGDDDGSS SSGGSSVAGS QSTLFKDSPL RTLKRKSSNM KRLSPAPQLG PSSDAHTSYY SESLVHESWF PPRSSLEELH GDANWGEDLR VRRRRGTGGS ESSRASGLVG RKATEDFLGS SSGYSSEDDY VGYSDVDQQS SSSRLRSAVS RAGSLLWMVA TSPGRLFRLL YWWAGTTWYR LTTAASLLDV FVLTRRFSSL KTFLWFLLPL LLLTCLTYGA WYFYPYGLQT FHPALVSWWA AKDSRRPDEG WEARDSSPHF QAEQRVMSRV HSLERRLEAL AAEFSSNWQK EAMRLERLEL RQGAPGQGGG GGLSHEDTLA LLEGLVSRRE AALKEDFRRE TAARIQEELS ALRAEHQQDS EDLFKKIVRA SQESEARIQQ LKSEWQSMTQ ESFQESSVKE LRRLEDQLAG LQQELAALAL KQSSVAEEVG LLPQQIQAVR DDVESQFPAW ISQFLARGGG GRVGLLQREE MQAQLRELES KILTHVAEMQ GKSAREAAAS LSLTLQKEGV IGVTEEQVHH IVKQALQRYS EDRIGLADYA LESGGASVIS TRCSETYETK TALLSLFGIP LWYHSQSPRV ILQPDVHPGN CWAFQGPQGF AVVRLSARIR PTAVTLEHVP KALSPNSTIS SAPKDFAIFG FDEDLQQEGT LLGKFTYDQD GEPIQTFHFQ APTMATYQVV ELRILTNWGH PEYTCIYRFR VHGEPAH