SUN2_ARATH » Protein SAD1/UNC-84 domain protein 2

SUN2_ARATH » Protein SAD1/UNC-84 domain protein 2
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Topology in Nuclear inner membrane
Topologyintermembrane space
nucleus matrix side
SUN2_ARATH » Protein SAD1/UNC-84 domain protein 2 »
Hydrophobic Thickness 30.8 ± 2.2 Å
Tilt Angle 26 ± 1°
ΔGtransfer -22.3 kcal/mol
ΔGfold -10.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 108-131 (105-134)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 310-446, PDBID: 3UNP, Subunit A, Seq Identity:41%, Sad1 / UNC-like C-terminal

UniProt annotation for SUN2_ARATH » Protein SAD1/UNC-84 domain protein 2
FUNCTION: Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments (PubMed:24667841). Required for the maintenance and/or formation of polarized nuclear shape in root hairs (PubMed:21294795). Modulates the anchoring and mobility of WIP proteins in the nuclear envelope (NE) (PubMed:22270916).
UniProt features for SUN2_ARATH » Protein SAD1/UNC-84 domain protein 2
CHAIN 1 455 Protein SAD1/UNC-84 domain protein 2.

DOMAIN 285 447 SUN.

COILED 201 225

MOTIF 88 95 Nuclear localization signal.

Amino Acid Sequence for SUN2_ARATH » Protein SAD1/UNC-84 domain protein 2
MSASTVSITA SPRTIRRTPV LSGEKKSNFD FPPSESHANA AIGESSAGTN KDLIRAEAAG ERSNTYDVGP VTRKSGSTAT GTNTTTTQRR TRKSQGNKID RGKWKTVVRV FAKQFGALLL LVGLIQLIRK LTLKDSSLSS SNFPIETEMV LSELESRISA VDGLVKTTTK MMQVQVEFLD KKMDSESRAL RQTIDSTSSV LHSELKKVES KTERLQVSVD ELNAKPLVSR EELERVYEEL KKGKVGDSDV NIDKLRAYAR DIVEKEIGKH VADGLGRVDY ALASGGAFVM GHSDPFLVGN GRNWFGTSRR RVHSKAVKML TPSFGEPGQC FPLKGSNGYV LVRLRAPIIP EAVTLEHVSK AVAYDRSSAP KDCRVSGWLG DIDMETETMP LLTEFSYDLD RSNAQTFDIA DSAHSGLVNT VRLDFNSNHG SSSHTCIYRF RVHGRELDSV SVAHA