SUN1_HUMAN » SUN domain-containing protein 1

SUN1_HUMAN » SUN domain-containing protein 1
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Topology in Nuclear inner membrane
Topologyintermembrane space
nucleus matrix side
SUN1_HUMAN » SUN domain-containing protein 1 » Protein unc-84 homolog A;Sad1/unc-84 protein-like 1;
Hydrophobic Thickness 32.2 ± 3.4 Å
Tilt Angle 10 ± 9°
ΔGtransfer -24.0 kcal/mol
ΔGfold -14.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology In
TM Segments 312-334 (311-336)
Pathways

Cell Cycle (Reactome)

Meiosis (Reactome)

PDB none
OPM none
Complexes none
Interactions

ESR1, Complex: SUN1:ESR1, PubMed

SYNE1, Complex: SYNE1:SUN1, PubMed

SYNE2, Complex: SUN1:SYNE2, PubMed

Domains

AA: 62-318, Mitochondrial RNA binding protein MRP

AA: 675-810, PDBID: 3UNP, Subunit A, Seq Identity:66%, Sad1 / UNC-like C-terminal

UniProt annotation for SUN1_HUMAN » SUN domain-containing protein 1
FUNCTION: Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non- coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity). Required for efficient localization of SYNE4 in the nuclear envelope (By similarity).

SUBUNIT: Dimers and tetramers (By similarity). Core component of the LINC complex which is composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins. SUN domain-containing proteins interact with A-type lamins of the nuclear lamina, while at the other end of the complex, nesprins interact with unique cytoskeletal components. May interact with SYNE1, SYNE2 and SYNE3. May interact with SYNE4 (By similarity). Interacts with A-type lamin with a strong preference for unprocessed A-type lamin compared with the mature protein. Interaction with lamins B1 and C is hardly detectable. Interacts with TSNAX (By similarity). Interacts with EMD and NAT10. Associates with the nuclear pore complex (NPC) (By similarity). Interacts with CCDC155 (via the last 22 AA); this interaction mediates CCDC155 telomere localization. Interacts with CCDC79/TERB1; promoting the accumulation of the LINC complex complexes at the telomere-nuclear envelope attachment sites (By similarity).

DOMAIN: The SUN domain may play a role in the nuclear anchoring and/or migration.

UniProt features for SUN1_HUMAN » SUN domain-containing protein 1
CHAIN 1 812 SUN domain-containing protein 1.
DOMAIN 649 811 SUN.
REGION 1 138 LMNA-binding.
REGION 209 302 SYNE2-binding.
REGION 223 302 EMD-binding.
COILED 393 430 Potential.
COILED 455 493 Potential.
COILED 501 523 Potential.
Amino Acid Sequence for SUN1_HUMAN » SUN domain-containing protein 1
MDFSRLHMYS PPQCVPENTG YTYALSSSYS SDALDFETEH KLDPVFDSPR MSRRSLRLAT TACTLGDGEA VGADSGTSSA VSLKNRAART TKQRRSTNKS AFSINHVSRQ VTSSGVSHGG TVSLQDAVTR RPPVLDESWI REQTTVDHFW GLDDDGDLKG GNKAAIQGNG DVGAAAATAH NGFSCSNCSM LSERKDVLTA HPAAPGPVSR VYSRDRNQKC DDCKGKRHLD AHPGRAGTLW HIWACAGYFL LQILRRIGAV GQAVSRTAWS ALWLAVVAPG KAASGVFWWL GIGWYQFVTL ISWLNVFLLT RCLRNICKFL VLLIPLFLLL AGLSLRGQGN FFSFLPVLNW ASMHRTQRVD DPQDVFKPTT SRLKQPLQGD SEAFPWHWMS GVEQQVASLS GQCHHHGENL RELTTLLQKL QARVDQMEGG AAGPSASVRD AVGQPPRETD FMAFHQEHEV RMSHLEDILG KLREKSEAIQ KELEQTKQKT ISAVGEQLLP TVEHLQLELD QLKSELSSWR HVKTGCETVD AVQERVDVQV REMVKLLFSE DQQGGSLEQL LQRFSSQFVS KGDLQTMLRD LQLQILRNVT HHVSVTKQLP TSEAVVSAVS EAGASGITEA QARAIVNSAL KLYSQDKTGM VDFALESGGG SILSTRCSET YETKTALMSL FGIPLWYFSQ SPRVVIQPDI YPGNCWAFKG SQGYLVVRLS MMIHPAAFTL EHIPKTLSPT GNISSAPKDF AVYGLENEYQ EEGQLLGQFT YDQDGESLQM FQALKRPDDT AFQIVELRIF SNWGHPEYTC LYRFRVHGEP VK