SUN1_DICDI » SUN domain-containing protein 1

SUN1_DICDI » SUN domain-containing protein 1
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Topology in Nuclear inner membrane
Topologyintermembrane space
nucleus matrix side
SUN1_DICDI » SUN domain-containing protein 1 »
Hydrophobic Thickness 31.6 ± 1.6 Å
Tilt Angle 22 ± 0°
ΔGtransfer -21.9 kcal/mol
ΔGfold -16.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 288-312 (288-314)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 713-859, PDBID: 3UNP, Subunit A, Seq Identity:37%, Sad1 / UNC-like C-terminal

UniProt annotation for SUN1_DICDI » SUN domain-containing protein 1
FUNCTION: May have an important role in defining the spacing of the nuclear envelope lumen. Essential for centrosome attachment to the nucleus, maintenance of correct ploidy, proper mitosis, association of the centromere cluster with the centrosome and the maintenance of genome stability. Requires direct chromatin binding for inner nuclear membrane targeting.

SUBUNIT: Homodimer and homooligomer.

UniProt features for SUN1_DICDI » SUN domain-containing protein 1
CHAIN 1 905 Sun domain-containing protein 1.
DOMAIN 662 860 SUN.
COILED 170 221 Potential.
COILED 359 456 Potential.
COILED 504 609 Potential.
COILED 864 901 Potential.
Amino Acid Sequence for SUN1_DICDI » SUN domain-containing protein 1
MSGDYKPNYQ SSPSRKRLPL QSKDQASIYK YQTPSTLNLY NNTVNNNSSN NSNNHLLHNS NPNSSYLYDS SKQYSNQINI RNNSNSNSNT NNITSKKASS SYSINNKVDH NSHNNNDDDD IEDDVDINYS TNNASSNILH NRFSNSNKDD SYIDYSTDEN PKILKQPQPL YNHLNNQIQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQRNNNNNS NSSNNNNTST TIKRNNQQID NNSNKNIISK FIGDPWKNFY YGSNKSLWPF ERNNNSNNSS NNNNKVNFKQ AIWIFIFSVL FIGCLLGLFS TNFYGIHIYF PSFSTTKTNS PFNSTNNNIQ FSNLITKEQL YPIIDEYFKK NEILKSYNKL FEKIENDIKY LSEREQYKDI INEIKEELKL VKLSNMDEDR VNQLISKMIN HYNNNENNKQ ELKELLSKSI EELTKLKSDS KEQLIQISTE SMNQLGQLKS ESINQLGQVK SESIDKFQST LKSLSKEEQS KIEREFNHQF NQLNKDADQL LSQHSLKIEK LREEINENQQ SSLLKLTQEY KQLEERLKEF SSKLQQSISS SSMDQFESWK LVFIKDIEER INKESSKLTN QYIQLTQQFT KIQSFIKDNP SIDSLTNTIE SLEGIKLLIE DILEVYSADK IAKVDYALGL AGASIEYNAL HYRVSETYPP IKGSGSGSGS GGANGNSLGL YYYNLATNWI FPQPKPNPPE TILDPMVNTG SCWGFYTGNG TIVIRLAKKI AITEVTMEHI SSNISHHIDS APKEFQVFGL INSSDIGQSL GVFTYDTTIN RHLQTFKVNK IQSTTTTTTN QDQNDDDNIQ EFSHVALRIL SNHGYRYTCI YRFRVHGYQI PHPEQEQIQI IQEEQSFKQE EINQQQIEQI EQIEQIEKQQ QSDEL