|SUB_ARATH » Protein STRUBBELIG » Leucine-rich repeat receptor kinase-like protein SUB;Protein SCRAMBLED;|
|Hydrophobic Thickness||33.2 ± 2.2 Å|
|Tilt Angle||29 ± 0°|
|Links||UniProtKB, Pfam, Interpro, iHOP, STRING|
|TM Segments||342-366 (338-369)|
MRH1, Complex: MRH1:SUB
|UniProt annotation for SUB_ARATH » Protein STRUBBELIG|
|FUNCTION: Regulates the expression of transcription factors that define the cell fates. Acts in a non-cell-autonomous fashion, functions in a radial inside-out signaling process, and mediates cell morphogenesis and cell fate across clonally distinct cell layers in floral primordia, developing ovules, and root meristems. Seems to be required for the regulation of cell shape and the orientation of the mitotic division plane. Involved in root hair specification, in the formation of the outer integument and the shape of organs such as carpels and petals and is necessary for the shape and height of the stem. Non-functional SUB proteins are retained in the endoplasmic reticulum and degraded by endoplasmic reticulum-associated degradation (ERAD). ENZYME REGULATION: Regulated at the post-transcriptional level. SUBUNIT: Interacts (via intra-cellular domain) with AN; this interaction is not required for correct subcellular localization and recycling of SUB. TISSUE SPECIFICITY: Expressed in leaves, stems, inflorescences, flower buds and developing root epidermis. DEVELOPMENTAL STAGE: Required for epidermal patterning during postembryonic root development, but not involved in hypocotyl development. DOMAIN: The protein kinase domain is catalytically inactive, but nevertheless important for SUB function. MISCELLANEOUS: Cannot be functionally replaced by the SRF1 to SRF8 proteins. MISCELLANEOUS: The sub/scm phenotype is sensitive to ecotype and is greatly reduced in cv. Columbia background. MISCELLANEOUS: Phosphorylation of Thr-486, Thr-494 or Ser-656 is not required for SUB function.|
|UniProt features for SUB_ARATH » Protein STRUBBELIG|
SIGNAL 1 24 Potential. |
CHAIN 25 768 Protein STRUBBELIG.
REPEAT 94 115 LRR 1.
REPEAT 116 139 LRR 2.
REPEAT 140 162 LRR 3.
REPEAT 164 186 LRR 4.
REPEAT 188 210 LRR 5.
REPEAT 211 231 LRR 6.
DOMAIN 497 768 Protein kinase.
|Amino Acid Sequence for SUB_ARATH » Protein STRUBBELIG|
|MSFTRWEVFF GLSVLALTMP FSAGVTNLRD VSAINNLYIT LGAPSLHHWL AFGGDPCGEK WQGVVCDSSN ITEIRIPGMK VGGGLSDTLA DFSSIQVMDF SSNHISGTIP QALPSSIRNL SLSSNRFTGN IPFTLSFLSD LSELSLGSNL LSGEIPDYFQ QLSKLTKLDL SSNILEGHLP SSMGDLASLK ILYLQDNKLT GTLDVIEDLF LTDLNVENNL FSGPIPPNLL KIPNFKKDGT PFNTSIITPP PPPVVDPPPA THRAPPVPRI PPVSGVPPAP FAPFAPLQPQ QHPPPSPPLV WSPPSSDNGG GDPWNSVSGQ PTLQISPPSG SGSGKFWSTQ RIILVVSSVA IIVLVSGLCV TLWRCCRSKI YNRYYSGARK DLQRPYFNKP PSQPTPTMGK VSREPMVKPF DGYGAGDRKY GYPMPQRAEE SRRAMPPTSY YNKDVNTPQK PLQQPPRQFQ SNDTASKRAA HFPPGLNSSS SATVFTIASL QQYTNNFSEE NIIGEGSIGN VYRAELRHGK FLAVKKLSNT INRTQSDGEF LNLVSNVLKL KRGHILELLG YCNEFGQRLL VYEYCPNGSL QDALHLDRKL HKKLTWNVRI NIALGASKAL QFLHEVCQPP VVHQNFKSSK VLLDGKLSVR VADSGLAYML PPRPTSQMAG YAAPEVEYGS YTCQSDVFSL GVVMLELLTG RRPFDRTRPR GHQTLAQWAI PRLHDIDALT RMVDPSLHGA YPMKSLSRFA DIISRSLQME PGFRPPISEI VQDLQHMI|