STYK1_HUMAN » Tyrosine-protein kinase STYK1

STYK1_HUMAN » Tyrosine-protein kinase STYK1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
STYK1_HUMAN » Tyrosine-protein kinase STYK1 » Serine/threonine/tyrosine kinase 1;Novel oncogene with kinase domain;Protein PK-unique;
Hydrophobic Thickness 32.8 ± 1.2 Å
Tilt Angle 1 ± 0°
ΔGtransfer -51.3 kcal/mol
ΔGfold -24.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 24-50 (21-53)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 114-380, PDBID: 4AOJ, Subunit C, Seq Identity:26%, Protein tyrosine kinase

UniProt annotation for STYK1_HUMAN » Tyrosine-protein kinase STYK1
FUNCTION: Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3"-kinases (PI3K) pathways (By similarity).

CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

TISSUE SPECIFICITY: Widely expressed. Highly expressed in brain, placenta and prostate. Expressed in tumor cells such as hepatoma cells L-02, cervix carcinoma cells HeLa, ovary cancer cells Ho8910 and chronic myelogenous leukemia cells K-562, but not in other tumor cells such as epidermoid carcinoma (A-431). Undetectable in most normal lung tissues, widely expressed in lung cancers.

UniProt features for STYK1_HUMAN » Tyrosine-protein kinase STYK1
CHAIN 1 422 Tyrosine-protein kinase STYK1.
DOMAIN 114 384 Protein kinase.
ACT_SITE 251 251 Proton acceptor (By similarity).
Amino Acid Sequence for STYK1_HUMAN » Tyrosine-protein kinase STYK1
MGMTRMLLEC SLSDKLCVIQ EKQYEVIIVP TLLVTIFLIL LGVILWLFIR EQRTQQQRSG PQGIAPVPPP RDLSWEAGHG GNVALPLKET SVENFLGATT PALAKLQVPR EQLSEVLEQI CSGSCGPIFR ANMNTGDPSK PKSVILKALK EPAGLHEVQD FLGRIQFHQY LGKHKNLVQL EGCCTEKLPL YMVLEDVAQG DLLGFLWTCR RDVMTMDGLL YDLTEKQVYH IGKQVLLALE FLQEKHLFHG DVAARNILMQ SDLTAKLCGL GLAYEVYTRG AISSTQTIPL KWLAPERLLL RPASIRADVW SFGILLYEMV TLGAPPYPEV PPTSILEHLQ RRKIMKRPSS CTHTMYSIMK SCWRWREADR PSPRELRLRL EAAIKTADDE AVLQVPELVV PELYAAVAGI RVESLFYNYS ML