STX8_YEAST » Syntaxin-8

STX8_YEAST » Syntaxin-8
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Topology in Endosome membrane
Topologyendosome lumenal side
cytoplasmic side
STX8_YEAST » Syntaxin-8 » SNARE protein related to mammalian syntaxin 8;ULP1-interacting protein 2;
Hydrophobic Thickness 29.6 ± 2.8 Å
Tilt Angle 2 ± 1°
ΔGtransfer -24.9 kcal/mol
ΔGfold -17.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 236-255 (235-255)
Pathways

SNARE interactions in vesicular transport (KEGG)

PDB none
OPM none
Complexes

STX7:VTI1B:VAMP8:STX8_MOUSE

Interactions

MNN10, Complex: MNN10:STX8

NYV1, Complex: STX8:NYV1, PubMed

PEP12, Complex: RSSA1:PDC1:ADH1:FKS1:HSP72:HSP75:GCN1:EF3A:GBB:AKR1:YKT6:VTI1:PEP12:STX8, PubMed

SNC1, Complex: STX8:SNC1, PubMed

VAM3, Complex: STX8:VAM3, PubMed

VTI1, Complex: VTI1:STX8, PubMed

YHO0, Complex: STX8:YHO0, PubMed

Domains

AA: 169-231, PDBID: 1kil, Subunit D, Seq Identity:30%, SNARE domain

UniProt annotation for STX8_YEAST » Syntaxin-8
FUNCTION: t-SNARE which may play a role in determining the specificity of membrane fusion, protein transport and vesicle trafficking within the Golgi/endosomal and plasma membrane/endosomal systems.

SUBUNIT: Interacts with PEP12, VTI1 and the SNC SNARE complex proteins.

UniProt features for STX8_YEAST » Syntaxin-8
CHAIN 1 255 Syntaxin-8.
DOMAIN 164 228 t-SNARE coiled-coil homology.
Amino Acid Sequence for STX8_YEAST » Syntaxin-8
MDVLKLGYEL DQLSDLVEER TRLVSVLKLA PTSNDNVTLK RQLGSILELL QKCAPNDELI SRYNTILDKI PDTAVDKELY RFQQQVARNT DEVSKESLKK VRFKNDDELT VMYKDDDEQD EESPLPSTHT PYKDEPLQSQ LQSQSQPQPP QPMVSNQELF INQQQQLLEQ DSHLGALSQS IGRTHDISLD LNNEIVSQND SLLVDLENLI DNNGRNLNRA SRSMHGFNNS RFKDNGNCVI ILVLIVVLLL LLLVL