STX8A_DICDI » Syntaxin-8A

STX8A_DICDI » Syntaxin-8A
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Topology in Endosome membrane
Topologyendosome lumenal side
cytoplasmic side
STX8A_DICDI » Syntaxin-8A »
Hydrophobic Thickness 29.8 ± 2.8 Å
Tilt Angle 2 ± 6°
ΔGtransfer -23.2 kcal/mol
ΔGfold -21.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 133-152 (131-152)
Pathways none
PDB none
OPM none
Complexes none
Interactions

STX7A, Complex: STX7A:STX8A, PubMed

Domains

AA: 96-148, PDBID: 2NPS, Subunit D, Seq Identity:32%, SNARE domain

UniProt annotation for STX8A_DICDI » Syntaxin-8A
FUNCTION: Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for fusion of late endosomes with lysosomes and homotypic lysosomal fusion.

SUBUNIT: Component of the SNARE complex composed of syn7A, syn8A, vamp7A and vti1A.

UniProt features for STX8A_DICDI » Syntaxin-8A
CHAIN 1 152 Syntaxin-8A.
DOMAIN 60 122 t-SNARE coiled-coil homology.
Amino Acid Sequence for STX8A_DICDI » Syntaxin-8A
MNNNNNFNSN FNSNRISSTQ PYLSDDARNA LFEGKDRKWG NNNNNNYDTL SNQDVFEKQK RDMEEQDKML DALSGSISRV KDTAITINKT AQEQTDMLDE LDVHVDSTSA RMRNTTKNLI TLTQQSKTTG YCSAICFLLL VLLVIIILAS VL