STX7_HUMAN » Syntaxin-7

STX7_HUMAN » Syntaxin-7
Magnify STX7_HUMAN » Syntaxin-7Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Endosome membrane
Topologyendosome lumenal side
cytoplasmic side
STX7_HUMAN » Syntaxin-7 »
Hydrophobic Thickness 35.6 ± 4.6 Å
Tilt Angle 1 ± 1°
ΔGtransfer -27.7 kcal/mol
ΔGfold -23.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology In
TM Segments 236-259 (229-260)
Pathways

Neuronal System (Reactome)

Phagosome (KEGG)

SNARE interactions in vesicular transport (KEGG)

PDB none
OPM none
Complexes

STX7:VTI1B:VAMP8:STX8_MOUSE

Interactions

CREB3, Complex: STX7:CREB3

SCO2, Complex: STX7:SCO2

STX4, Complex: STX4:STX7

STX6, Complex: STX6:STX7:VAMP4:STX8, PubMed

STX8, Complex: STX7:STX8:VAMP8:VTI1B, PDBID: 1gl2

VAMP3, Complex: STX7:VAMP3, PubMed

VAMP4, Complex: STX7:VAMP4, PubMed

VAMP7, Complex: STX7:VAMP7, PubMed

VAMP8, Complex: STX7:STX8:VAMP8:VTI1B, PDBID: 1gl2

VTI1A, Complex: STX7:VTI1A, PubMed

VTI1B, Complex: STX7:STX8:VAMP8:VTI1B, PDBID: 1gl2

Domains

AA: 18-119, PDBID: 2DNX, Subunit A, Seq Identity:49%, Syntaxin-like protein

AA: 201-253, PDBID: 1GL2, Subunit B, Seq Identity:79%, SNARE domain

UniProt annotation for STX7_HUMAN » Syntaxin-7
FUNCTION: May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.

SUBUNIT: Forms a SNARE complex with VTI1B, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes (By similarity). Interacts with VPS11, VPS16 and VPS18. Interacts with VPS33A.

TISSUE SPECIFICITY: Highest expression is found in placenta followed by heart, skeletal muscle, kidney and brain. Low expression is found in pancreas, lung and liver.

UniProt features for STX7_HUMAN » Syntaxin-7
CHAIN 2 261 Syntaxin-7.
DOMAIN 165 227 t-SNARE coiled-coil homology.
COILED 47 69 Potential.
Amino Acid Sequence for STX7_HUMAN » Syntaxin-7
MSYTPGVGGD PAQLAQRISS NIQKITQCSV EIQRTLNQLG TPQDSPELRQ QLQQKQQYTN QLAKETDKYI KEFGSLPTTP SEQRQRKIQK DRLVAEFTTS LTNFQKVQRQ AAEREKEFVA RVRASSRVSG SFPEDSSKER NLVSWESQTQ PQVQVQDEEI TEDDLRLIHE RESSIRQLEA DIMDINEIFK DLGMMIHEQG DVIDSIEANV ENAEVHVQQA NQQLSRAADY QRKSRKTLCI IILILVIGVA IISLIIWGLN H