STX7A_DICDI » Syntaxin-7A

STX7A_DICDI » Syntaxin-7A
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Topology in Endosome membrane
Topologyendosome lumenal side
cytoplasmic side
STX7A_DICDI » Syntaxin-7A »
Hydrophobic Thickness 34.4 ± 3.6 Å
Tilt Angle 0 ± 1°
ΔGtransfer -28.5 kcal/mol
ΔGfold -25.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 331-354 (320-355)
Pathways

Phagosome (KEGG)

SNARE interactions in vesicular transport (KEGG)

PDB none
OPM none
Complexes none
Interactions

STX8A, Complex: STX7A:STX8A, PubMed

VAM7A, Complex: STX7A:VAM7A, PubMed

VTI1A, Complex: STX7A:VTI1A, PubMed

Domains

AA: 91-191, PDBID: 2DNX, Subunit A, Seq Identity:28%, Syntaxin-like protein

AA: 295-347, PDBID: 2NPS, Subunit B, Seq Identity:39%, SNARE domain

UniProt annotation for STX7A_DICDI » Syntaxin-7A
FUNCTION: Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for fusion of late endosomes with lysosomes and homotypic lysosomal fusion. May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles.

SUBUNIT: Component of the SNARE complex composed of syn7A, syn8A, vamp7A and vti1A. Interacts with nsfA, snpA and snpC.

UniProt features for STX7A_DICDI » Syntaxin-7A
CHAIN 1 356 Syntaxin-7A.
DOMAIN 259 321 t-SNARE coiled-coil homology.
Amino Acid Sequence for STX7A_DICDI » Syntaxin-7A
MYNNNNNFGG GGYNQGGGYN SGGYNNNGGG YNNNNGGYNN NNNNNGGYNN NRPQQQQQQQ QQYVNNNNNS FDNNGYGGDD DVTNNSDYQS TTRNIQQIQN AVQILTKLVQ LLGTPKDSMD TREKIRNCVD STTHLISSES GKVKNLTSLA SRSRDSKNKL LYQKLVKEFN NCLQQFKDIA QVATKKEKTT PLPVAPDHQQ PTTFGRNNNS NNNNQNNHFL NNQQPYYDDD NREDEHQSLM ESSRRQQLAQ IEAEREYQNS IIQERDEGIR KIEQSIVEIN EIFVDLSGLV AEQGVMINTI EASLESTTIN TKEGVNHLRE ASKNQKSSRN KMCWIVLILL IVCAVLGVIL FFTLRK