STX6_HUMAN » Syntaxin-6

STX6_HUMAN » Syntaxin-6
Magnify STX6_HUMAN » Syntaxin-6Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
STX6_HUMAN » Syntaxin-6 »
Hydrophobic Thickness 34.4 ± 2.4 Å
Tilt Angle 2 ± 1°
ΔGtransfer -29.6 kcal/mol
ΔGfold -24.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology In
TM Segments 233-255 (230-255)
Pathways

Neuronal System (Reactome)

SNARE interactions in vesicular transport (KEGG)

PDB 4j2c (A/C=3-110), 2nps (D=169-234)
OPM 2nps
Complexes

STX12:VAMP4:VTI1A:STX6_RAT

Interactions

CGAT1, Complex: STX6:CGAT1, PubMed

GOSR2, Complex: STX6:GOSR2

STX12, Complex: STX6:STX12:VTI1A, PubMed

STX12, Complex: STX6:VTI1A:STX12:VAMP4, PDBID: 2nps, PubMed

STX16, Complex: STX6:STX16, PubMed

STX4, Complex: STX6:VAMP2:VTI1B:VAMP7:STX4, PubMed

STX7, Complex: STX6:VAMP8:STX7:STX8, PubMed

VAMP3, Complex: VAMP3:STX6, PubMed

VAMP4, Complex: STX6:VAMP4:VTI1A, PDBID: 2nps

VAMP7, Complex: STX6:VAMP7, PubMed

VAMP8, Complex: STX6:VAMP8, PubMed

VTI1A, Complex: STX6:VAMP4:VTI1A, PDBID: 2nps

Domains

AA: 5-103, PDBID: 4J2C, Subunit A, Seq Identity:100%, Syntaxin 6, N-terminal

AA: 199-251, PDBID: 2NPS, Subunit D, Seq Identity:100%, SNARE domain

UniProt annotation for STX6_HUMAN » Syntaxin-6
FUNCTION: Involved in intracellular vesicle trafficking.

SUBUNIT: Binds EEA1. Interacts with VPS45A. Interacts with MARCH2 and MARCH3 (By similarity). Interacts with GOPC. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A.

UniProt features for STX6_HUMAN » Syntaxin-6
CHAIN 2 255 Syntaxin-6.
DOMAIN 163 225 t-SNARE coiled-coil homology.
COILED 41 74 Potential.
Amino Acid Sequence for STX6_HUMAN » Syntaxin-6
MSMEDPFFVV KGEVQKAVNT AQGLFQRWTE LLQDPSTATR EEIDWTTNEL RNNLRSIEWD LEDLDETISI VEANPRKFNL DATELSIRKA FITSTRQVVR DMKDQMSTSS VQALAERKNR QALLGDSGSQ NWSTGTTDKY GRLDRELQRA NSHFIEEQQA QQQLIVEQQD EQLELVSGSI GVLKNMSQRI GGELEEQAVM LEDFSHELES TQSRLDNVMK KLAKVSHMTS DRRQWCAIAI LFAVLLVVLI LFLVL