STX5_HUMAN » Syntaxin-5

STX5_HUMAN » Syntaxin-5
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
STX5_HUMAN » Syntaxin-5 »
Hydrophobic Thickness 31.2 ± 3.2 Å
Tilt Angle 9 ± 5°
ΔGtransfer -32.5 kcal/mol
ΔGfold -24.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology In
TM Segments 334-355 (331-355)
Pathways

Neuronal System (Reactome)

SNARE interactions in vesicular transport (KEGG)

PDB 3efo (C=242-248)
OPM none
Complexes none
Interactions

APLP1, Complex: APLP1:STX5, PubMed

BET1L, Complex: BET1L:STX5, PubMed

BET1, Complex: BET1:STX5, PubMed

GOSR1, Complex: GOSR1:STX5, PubMed

GOSR2, Complex: GOSR2:STX5, PubMed

IMMT, Complex: STX5:IMMT, PubMed

IMMT, Complex: MIC60:STX5, PubMed

KASH5, Complex: STX5:KASH5

SC22B, Complex: SC22B:STX5, PubMed

STX17, Complex: STX17:STX5, PubMed

STX4, Complex: STX4:STX5

TMED9, Complex: TMED9:STX5, PubMed

VAPB, Complex: VAPB:STX5, PubMed

VTI1B, Complex: VTI1B:STX5, PubMed

Domains

AA: 52-74, PDBID: 1MQS, Subunit B, Seq Identity:37%, Syntaxin-5 N-terminal, Sly1p-binding domain

AA: 299-351, PDBID: 3B5N, Subunit J, Seq Identity:33%, SNARE domain

UniProt annotation for STX5_HUMAN » Syntaxin-5
FUNCTION: Mediates endoplasmic reticulum to Golgi transport.

SUBUNIT: Part of a ternary complex containing STX5A, NSFL1C and VCP. Identified in a unique SNARE complex composed of the Golgi SNAREs GOSR1, GOSR2, YKT6 and VTI1A (By similarity). Interacts with COG4.

UniProt features for STX5_HUMAN » Syntaxin-5
CHAIN 1 355 Syntaxin-5.
DOMAIN 263 325 t-SNARE coiled-coil homology.
COILED 287 318 Potential.
Amino Acid Sequence for STX5_HUMAN » Syntaxin-5
MIPRKRYGSK NTDQGVYLGL SKTQVLSPAT AGSSSSDIAP LPPPVTLVPP PPDTMSCRDR TQEFLSACKS LQTRQNGIQT NKPALRAVRQ RSEFTLMAKR IGKDLSNTFA KLEKLTILAK RKSLFDDKAV EIEELTYIIK QDINSLNKQI AQLQDFVRAK GSQSGRHLQT HSNTIVVSLQ SKLASMSNDF KSVLEVRTEN LKQQRSRREQ FSRAPVSALP LAPNHLGGGA VVLGAESHAS KDVAIDMMDS RTSQQLQLID EQDSYIQSRA DTMQNIESTI VELGSIFQQL AHMVKEQEET IQRIDENVLG AQLDVEAAHS EILKYFQSVT SNRWLMVKIF LILIVFFIIF VVFLA