STX4_HUMAN » Syntaxin-4

STX4_HUMAN » Syntaxin-4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
STX4_HUMAN » Syntaxin-4 » Renal carcinoma antigen NY-REN-31;
Hydrophobic Thickness 40.8 ± 4.8 Å
Tilt Angle 0 ± 4°
ΔGtransfer -26.0 kcal/mol
ΔGfold -20.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology In
TM Segments 270-296 (262-296)
Pathways

Hemostasis (Reactome)

Membrane Trafficking (Reactome)

Neuronal System (Reactome)

SNARE interactions in vesicular transport (KEGG)

Vasopressin-regulated water reabsorption (KEGG)

PDB none
OPM none
Complexes none
Interactions

BET1, Complex: STX4:BET1

GIMA5, Complex: STX4:GIMA5

GOSR2, Complex: STX4:GOSR2

SC22B, Complex: STX4:SC22B, PubMed

STX12, Complex: STX4:STX12

STX16, Complex: STX4:STX16

STX3, Complex: STX3:STX4

STX5, Complex: STX4:STX5

STX6, Complex: STX6:VAMP2:VTI1B:VAMP7:STX4, PubMed

STX7, Complex: STX4:STX7

STX8, Complex: STX4:STX8

SYT1, Complex: STX4:SYT1, PubMed

SYT4, Complex: SYT4:STX4, PubMed

SYT7, Complex: SYT7:STX4, PubMed

VAMP1, Complex: VAMP1:STX4, PubMed

VAMP2, Complex: SNAA:STX4:NSF:VAMP3:VAMP2, PubMed

VAMP3, Complex: STX4:VAMP3, PubMed

VAMP4, Complex: STX4:VAMP4, PubMed

VAMP5, Complex: STX4:VAMP5

VAMP7, Complex: VAMP7:STX4, PubMed

VAMP8, Complex: VAPA:VAMP8:STX4:VAPB, PubMed

VAPB, Complex: VAPB:STX4, PubMed

VTI1B, Complex: STX4:VTI1B

Domains

AA: 38-235, PDBID: 1BR0, Subunit A, Seq Identity:46%, Syntaxin

AA: 236-292, PDBID: 1HVV, Subunit B, Seq Identity:45%, SNARE domain

UniProt annotation for STX4_HUMAN » Syntaxin-4
FUNCTION: Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones.

SUBUNIT: Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that interacts with SYT7 during lysosomal exocytosis. Found in a complex with VAMP8 and SNAP23. Detected in a complex with SNAP23 and STXBP4. Interacts with VAMP2. Interacts with SNAP23 and SNAPIN. Interacts with LLGL1. Interacts (via C- terminus) with CENPF. Interacts with DOC2B. Interacts with STXBP6. Interacts with STXBP3; excludes interaction with DOC2B and SNAP25. Interacts with STXBP4; excludes interaction with VAMP2 (By similarity).

TISSUE SPECIFICITY: Expressed in neutrophils and neutrophil- differentiated HL-60 cells. Expression in neutrophils increases with differentiation.

UniProt features for STX4_HUMAN » Syntaxin-4
CHAIN 1 297 Syntaxin-4.
DOMAIN 200 262 t-SNARE coiled-coil homology.
REGION 154 297 Interaction with CENPF (By similarity).
COILED 43 163 Potential.
Amino Acid Sequence for STX4_HUMAN » Syntaxin-4
MRDRTHELRQ GDDSSDEEDK ERVALVVHPG TARLGSPDEE FFHKVRTIRQ TIVKLGNKVQ ELEKQQVTIL ATPLPEESMK QELQNLRDEI KQLGREIRLQ LKAIEPQKEE ADENYNSVNT RMRKTQHGVL SQQFVELINK CNSMQSEYRE KNVERIRRQL KITNAGMVSD EELEQMLDSG QSEVFVSNIL KDTQVTRQAL NEISARHSEI QQLERSIREL HDIFTFLATE VEMQGEMINR IEKNILSSAD YVERGQEHVK TALENQKKAR KKKVLIAICV SITVVLLAVI IGVTVVG