STX3_HUMAN » Syntaxin-3

STX3_HUMAN » Syntaxin-3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
STX3_HUMAN » Syntaxin-3 »
Hydrophobic Thickness 34.8 ± 1.5 Å
Tilt Angle 1 ± 18°
ΔGtransfer -29.5 kcal/mol
ΔGfold -26.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology In
TM Segments 262-284 (257-288)
Pathways

Neuronal System (Reactome)

SNARE interactions in vesicular transport (KEGG)

Synaptic vesicle cycle (KEGG)

PDB none
OPM none
Complexes none
Interactions

SNPH, Complex: STX3:SNPH, PubMed

STX1A, Complex: CPLX3:STX3:VAMP2:CPLX1:CPLX4:STX1A:SNP25

STX4, Complex: STX3:STX4

SYT1, Complex: STX3:SYT1, PubMed

SYT4, Complex: SYT4:STX3, PubMed

SYT7, Complex: SYT7:STX3, PubMed

VAMP1, Complex: STX3:VAMP1, PubMed

VAMP2, Complex: VAMP2:STX3, PubMed

VAMP3, Complex: VAMP3:STX3, PubMed

VAMP7, Complex: VAMP7:STX3, PubMed

VAMP8, Complex: STX3:VAMP8, PubMed

Domains

AA: 32-226, PDBID: 1BR0, Subunit A, Seq Identity:70%, Syntaxin

AA: 227-279, PDBID: 1HVV, Subunit B, Seq Identity:61%, SNARE domain

UniProt annotation for STX3_HUMAN » Syntaxin-3
FUNCTION: Potentially involved in docking of synaptic vesicles at presynaptic active zones.
UniProt features for STX3_HUMAN » Syntaxin-3
CHAIN 1 289 Syntaxin-3.
DOMAIN 191 253 t-SNARE coiled-coil homology.
COILED 32 111 Potential.
Amino Acid Sequence for STX3_HUMAN » Syntaxin-3
MKDRLEQLKA KQLTQDDDTD AVEIAIDNTA FMDEFFSEIE ETRLNIDKIS EHVEEAKKLY SIILSAPIPE PKTKDDLEQL TTEIKKRANN VRNKLKSMEK HIEEDEVRSS ADLRIRKSQH SVLSRKFVEV MTKYNEAQVD FRERSKGRIQ RQLEITGKKT TDEELEEMLE SGNPAIFTSG IIDSQISKQA LSEIEGRHKD IVRLESSIKE LHDMFMDIAM LVENQGEMLD NIELNVMHTV DHVEKARDET KKAVKYQSQA RKKLIIIIVL VVVLLGILAL IIGLSVGLN