STX2_HUMAN » Syntaxin-2

STX2_HUMAN » Syntaxin-2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
STX2_HUMAN » Syntaxin-2 » Epimorphin;
Hydrophobic Thickness 34.6 ± 1.1 Å
Tilt Angle 6 ± 5°
ΔGtransfer -27.9 kcal/mol
ΔGfold -22.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology In
TM Segments 263-285 (256-286)
Pathways

Neuronal System (Reactome)

SNARE interactions in vesicular transport (KEGG)

Synaptic vesicle cycle (KEGG)

PDB none
OPM none
Complexes none
Interactions

SYT1, Complex: SYT1:STX2, PubMed

SYT4, Complex: SYT4:STX2, PubMed

SYT7, Complex: SYT7:STX2, PubMed

VAMP2, Complex: STX2:VAMP2, PubMed

VAMP3, Complex: STX2:VAMP3, PubMed

VAMP8, Complex: VAMP8:STX2, PubMed

VAPB, Complex: VAPB:STX2, PubMed

Domains

AA: 29-226, PDBID: 1BR0, Subunit A, Seq Identity:70%, Syntaxin

AA: 227-279, PDBID: 1HVV, Subunit B, Seq Identity:65%, SNARE domain

UniProt annotation for STX2_HUMAN » Syntaxin-2
FUNCTION: Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.

SUBUNIT: Interacts with SYT6 and SYT8; the interaction is Ca(2+)- dependent.

UniProt features for STX2_HUMAN » Syntaxin-2
CHAIN 1 288 Syntaxin-2.
DOMAIN 191 253 t-SNARE coiled-coil homology.
COILED 35 101 Potential.
Amino Acid Sequence for STX2_HUMAN » Syntaxin-2
MRDRLPDLTA CRKNDDGDTV VVVEKDHFMD DFFHQVEEIR NSIDKITQYV EEVKKNHSII LSAPNPEGKI KEELEDLNKE IKKTANKIRA KLKAIEQSFD QDESGNRTSV DLRIRRTQHS VLSRKFVEAM AEYNEAQTLF RERSKGRIQR QLEITGRTTT DDELEEMLES GKPSIFTSDI ISDSQITRQA LNEIESRHKD IMKLETSIRE LHEMFMDMAM FVETQGEMIN NIERNVMNAT DYVEHAKEET KKAIKYQSKA RRKKWIIIAV SVVLVVIIVL IIGLSVGK