STX1B_HUMAN » Syntaxin-1B

STX1B_HUMAN » Syntaxin-1B
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
STX1B_HUMAN » Syntaxin-1B » Syntaxin-1B1;Syntaxin-1B2;
Hydrophobic Thickness 33.2 ± 3.1 Å
Tilt Angle 7 ± 5°
ΔGtransfer -18.6 kcal/mol
ΔGfold -11.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 262-283 (256-286)
Pathways

Neuronal System (Reactome)

SNARE interactions in vesicular transport (KEGG)

Synaptic vesicle cycle (KEGG)

PDB none
OPM none
Complexes none
Interactions

VAMP1, Complex: VAMP1:STX1B, PubMed

VAMP2, Complex: STX1B:VAMP2, PubMed

VAMP8, Complex: VAMP8:STX1B, PubMed

VAPB, Complex: STX1B:VAPB, PubMed

Domains

AA: 29-226, PDBID: 1BR0, Subunit A, Seq Identity:84%, Syntaxin

AA: 227-279, PDBID: 1HVV, Subunit B, Seq Identity:90%, SNARE domain

UniProt annotation for STX1B_HUMAN » Syntaxin-1B
FUNCTION: Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity).

SUBUNIT: Interacts with OTOF. Interacts with SYT6 and SYT8; the interaction is Ca(2+)-dependent (By similarity).

DISEASE: Generalized epilepsy with febrile seizures plus 9 (GEFSP9) OMIM: An autosomal dominant neurologic disorder characterized by febrile and/or afebrile seizures manifesting in early childhood. Seizure are variable and include generalized tonic-clonic, atonic, myoclonic, complex partial, and absence types. Most patients have remission of seizures later in childhood with no residual neurologic deficits. Rarely, patients may show mild developmental delay or mild intellectual disabilities. mutations affecting the gene represented in this entry.

UniProt features for STX1B_HUMAN » Syntaxin-1B
CHAIN 1 288 Syntaxin-1B.
DOMAIN 191 253 t-SNARE coiled-coil homology.
COILED 29 104 Potential.
Amino Acid Sequence for STX1B_HUMAN » Syntaxin-1B
MKDRTQELRS AKDSDDEEEV VHVDRDHFMD EFFEQVEEIR GCIEKLSEDV EQVKKQHSAI LAAPNPDEKT KQELEDLTAD IKKTANKVRS KLKAIEQSIE QEEGLNRSSA DLRIRKTQHS TLSRKFVEVM TEYNATQSKY RDRCKDRIQR QLEITGRTTT NEELEDMLES GKLAIFTDDI KMDSQMTKQA LNEIETRHNE IIKLETSIRE LHDMFVDMAM LVESQGEMID RIEYNVEHSV DYVERAVSDT KKAVKYQSKA RRKKIMIIIC CVVLGVVLAS SIGGTLGL