STX1A_HUMAN » Syntaxin-1A

STX1A_HUMAN » Syntaxin-1A
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Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
STX1A_HUMAN » Syntaxin-1A » Neuron-specific antigen HPC-1;
Hydrophobic Thickness 33.4 ± 2.8 Å
Tilt Angle 7 ± 5°
ΔGtransfer -19.5 kcal/mol
ΔGfold -13.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 263-284 (257-287)
Pathways

Amphetamine addiction (KEGG)

Insulin secretion (KEGG)

Neuronal System (Reactome)

SNARE interactions in vesicular transport (KEGG)

Synaptic vesicle cycle (KEGG)

PDB none
OPM 1kil (RAT), 2m8r (RAT), 3hd7 (RAT)
Complexes

CPLX1:VAMP2:SNP25:STX1A_RAT

SNP25:VAMP2:STX1A_RAT

VAMP2:NSF:SNAA:STX1A_RAT

STX1A:STX1A_RAT

Interactions

ATP4B, Complex: ATP4B:STX1A, PubMed

SNPH, Complex: SNPH:STX1A, PubMed

STX1A, Complex: Homotetramer of syntaxin 1A, PDBID: 1HVV

STX3, Complex: CPLX3:STX3:VAMP2:CPLX1:CPLX4:STX1A:SNP25

STX8, Complex: STX1A:STX8, PubMed

SYBU, Complex: STX1A:KINH:SYBU, PubMed

SYT1, Complex: STX1A:CPLX1:SYT1:SNAA, PubMed

SYT4, Complex: STX1A:SYT4, PubMed

SYT7, Complex: STX1A:SYT7, PubMed

VAMP1, Complex: STX1A:VAMP1, PubMed

VAMP2, Complex: CPLX1:SNP25:STX1A:VAMP2, PDBID: 1kil

VAMP5, Complex: STX1A:VAMP5

VAMP7, Complex: STX1A:VAMP7, PubMed

VAMP8, Complex: STX1A:VAMP8, PubMed

VAPB, Complex: VAPB:STX1A, PubMed

Domains

AA: 30-227, PDBID: 1BR0, Subunit A, Seq Identity:100%, Syntaxin

AA: 228-280, PDBID: 1HVV, Subunit B, Seq Identity:98%, SNARE domain

UniProt annotation for STX1A_HUMAN » Syntaxin-1A
FUNCTION: Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.

SUBUNIT: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds to CPLX1. Binds SYTL4 and STXBP6. Found in a ternary complex with STX1A and SNAP25. Interacts with OTOF and LGI3. Interacts with SLC6A4. Interacts with SYT6 and SYT8; the interaction is Ca(2+)-dependent (By similarity). Found in a complex with VAMP8 and SNAP23. Interacts with VAPA and SYBU. Interacts with STXBP1 and DAPK1.

TISSUE SPECIFICITY: Isoform 1 is highly expressed in embryonic spinal chord and ganglia and in adult cerebellum and cerebral cortex. Isoform 2 is expressed in heart, liver, fat, skeletal muscle, kidney and brain.

DISEASE: Note=STX1A is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.

UniProt features for STX1A_HUMAN » Syntaxin-1A
CHAIN 1 288 Syntaxin-1A.
DOMAIN 192 254 t-SNARE coiled-coil homology.
COILED 68 109 Potential.
Amino Acid Sequence for STX1A_HUMAN » Syntaxin-1A
MKDRTQELRT AKDSDDDDDV AVTVDRDRFM DEFFEQVEEI RGFIDKIAEN VEEVKRKHSA ILASPNPDEK TKEELEELMS DIKKTANKVR SKLKSIEQSI EQEEGLNRSS ADLRIRKTQH STLSRKFVEV MSEYNATQSD YRERCKGRIQ RQLEITGRTT TSEELEDMLE SGNPAIFASG IIMDSSISKQ ALSEIETRHS EIIKLENSIR ELHDMFMDMA MLVESQGEMI DRIEYNVEHA VDYVERAVSD TKKAVKYQSK ARRKKIMIII CCVILGIVIA STVGGIFA