STX18_HUMAN » Syntaxin-18

STX18_HUMAN » Syntaxin-18
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
STX18_HUMAN » Syntaxin-18 » Cell growth-inhibiting gene 9 protein;
Hydrophobic Thickness 33.0 ± 2.1 Å
Tilt Angle 6 ± 5°
ΔGtransfer -23.4 kcal/mol
ΔGfold -14.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 311-333 (309-333)
Pathways

Phagosome (KEGG)

SNARE interactions in vesicular transport (KEGG)

PDB none
OPM none
Complexes none
Interactions

NSG2, Complex: STX18:NSG2, PubMed

SC22B, Complex: STX18:SC22B, PubMed

SEC20, Complex: STX18:SEC20, PubMed

Domains

AA: 3-96, SNARE-complex protein Syntaxin-18 N-terminus

UniProt annotation for STX18_HUMAN » Syntaxin-18
FUNCTION: Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

SUBUNIT: Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L, and SEC22B. RINT1/TIP20L and ZW10 are associated with the complex through interaction with BNIP1/SEC20L. Interacts directly with USE1L and BNIP1/SEC20L.

TISSUE SPECIFICITY: Ubiquitous.

UniProt features for STX18_HUMAN » Syntaxin-18
CHAIN 1 335 Syntaxin-18.
DOMAIN 243 305 t-SNARE coiled-coil homology.
Amino Acid Sequence for STX18_HUMAN » Syntaxin-18
MAVDITLLFR ASVKTVKTRN KALGVAVGGG VDGSRDELFR RSPRPKGDFS SRAREVISHI GKLRDFLLEH RKDYINAYSH TMSEYGRMTD TERDQIDQDA QIFMRTCSEA IQQLRTEAHK EIHSQQVKEH RTAVLDFIED YLKRVCKLYS EQRAIRVKRV VDKKRLSKLE PEPNTKTRES TSSEKVSQSP SKDSEENPAT EERPEKILAE TQPELGTWGD GKGEDELSPE EIQMFEQENQ RLIGEMNSLF DEVRQIEGRV VEISRLQEIF TEKVLQQEAE IDSIHQLVVG ATENIKEGNE DIREAIKNNA GFRVWILFFL VMCSFSLLFL DWYDS