STX17_HUMAN » Syntaxin-17

STX17_HUMAN » Syntaxin-17
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
STX17_HUMAN » Syntaxin-17 »
Hydrophobic Thickness 31.0 ± 4.0 Å
Tilt Angle 14 ± 6°
ΔGtransfer -12.1 kcal/mol
ΔGfold -6.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 249-270 (249-280)
Pathways

SNARE interactions in vesicular transport (KEGG)

PDB 4wy4 (B=170-227)
OPM 4wy4
Complexes

SNP29:STX17:VAMP8_HUMAN

Interactions

CADH1, Complex: CADH1:STX17

EGFR, Complex: STX17:EGFR

STX5, Complex: STX17:STX5, PubMed

TLR2, Complex: STX17:TLR2

VAMP8, Complex: SNP29:STX17:VAMP8, PDBID: 4WY4

VTI1B, Complex: STX17:VTI1B

Domains

AA: 169-228, PDBID: 1kil, Subunit B, Seq Identity:33%, SNARE domain

UniProt annotation for STX17_HUMAN » Syntaxin-17
FUNCTION: SNAREs, Soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed).

SUBUNIT: Forms a SNARE complex composed of VAMP8, SNAP29 and STX17 involved in fusion of autophagosome with lysosome. May interact with VAMP7. May interact with VTI1B. Probably interacts with BET1, SCFD1 and SEC22B (By similarity). Interacts with PTPN2 and ABL1; involved in STX17 phosphorylation. Interacts with COPB1 (By similarity). Interacts with TMED9 and TMED10; the interaction is direct.

UniProt features for STX17_HUMAN » Syntaxin-17
CHAIN 1 302 Syntaxin-17.
DOMAIN 162 224 t-SNARE coiled-coil homology.
COILED 49 82 Potential.
COILED 103 127 Potential.
Amino Acid Sequence for STX17_HUMAN » Syntaxin-17
MSEDEEKVKL RRLEPAIQKF IKIVIPTDLE RLRKHQINIE KYQRCRIWDK LHEEHINAGR TVQQLRSNIR EIEKLCLKVR KDDLVLLKRM IDPVKEEASA ATAEFLQLHL ESVEELKKQF NDEETLLQPP LTRSMTVGGA FHTTEAEASS QSLTQIYALP EIPQDQNAAE SWETLEADLI ELSQLVTDFS LLVNSQQEKI DSIADHVNSA AVNVEEGTKN LGKAAKYKLA ALPVAGALIG GMVGGPIGLL AGFKVAGIAA ALGGGVLGFT GGKLIQRKKQ KMMEKLTSSC PDLPSQTDKK CS