|STX17_HUMAN » Syntaxin-17 »|
|Hydrophobic Thickness||31.0 ± 4.0 Å|
|Tilt Angle||14 ± 6°|
|Links||UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC|
|TM Segments||249-270 (249-280)|
CADH1, Complex: CADH1:STX17
EGFR, Complex: STX17:EGFR
TLR2, Complex: STX17:TLR2
VTI1B, Complex: STX17:VTI1B
|UniProt annotation for STX17_HUMAN » Syntaxin-17|
|FUNCTION: SNAREs, Soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed). SUBUNIT: Forms a SNARE complex composed of VAMP8, SNAP29 and STX17 involved in fusion of autophagosome with lysosome. May interact with VAMP7. May interact with VTI1B. Probably interacts with BET1, SCFD1 and SEC22B (By similarity). Interacts with PTPN2 and ABL1; involved in STX17 phosphorylation. Interacts with COPB1 (By similarity). Interacts with TMED9 and TMED10; the interaction is direct.|
|UniProt features for STX17_HUMAN » Syntaxin-17|
CHAIN 1 302 Syntaxin-17. |
DOMAIN 162 224 t-SNARE coiled-coil homology.
COILED 49 82 Potential.
COILED 103 127 Potential.
|Amino Acid Sequence for STX17_HUMAN » Syntaxin-17|
|MSEDEEKVKL RRLEPAIQKF IKIVIPTDLE RLRKHQINIE KYQRCRIWDK LHEEHINAGR TVQQLRSNIR EIEKLCLKVR KDDLVLLKRM IDPVKEEASA ATAEFLQLHL ESVEELKKQF NDEETLLQPP LTRSMTVGGA FHTTEAEASS QSLTQIYALP EIPQDQNAAE SWETLEADLI ELSQLVTDFS LLVNSQQEKI DSIADHVNSA AVNVEEGTKN LGKAAKYKLA ALPVAGALIG GMVGGPIGLL AGFKVAGIAA ALGGGVLGFT GGKLIQRKKQ KMMEKLTSSC PDLPSQTDKK CS|