STX12_HUMAN » Syntaxin-12

STX12_HUMAN » Syntaxin-12
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Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
STX12_HUMAN » Syntaxin-12 »
Hydrophobic Thickness 34.0 ± 2.8 Å
Tilt Angle 0 ± 0°
ΔGtransfer -49.4 kcal/mol
ΔGfold -26.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 248-274 (242-275)
Pathways

Neuronal System (Reactome)

Phagosome (KEGG)

PDB 2dnx (18-134)
OPM 2nps (RAT)
Complexes

STX12:VAMP4:VTI1A:STX6_RAT

Interactions

GOSR1, Complex: STX12:GOSR1, PubMed

NSG1, Complex: NSG1:STX12, PubMed

STX4, Complex: STX4:STX12

STX6, Complex: STX6:VTI1A:STX12:VAMP4, PDBID: 2nps, PubMed

VAMP2, Complex: STX12:SNP25:VAMP2:HGS, PubMed

VAMP2, Complex: VAMP3:VAMP2:SNP25:STX12:SNAB, PubMed

VAMP4, Complex: STX12:VAMP4:VTI1A, PubMed

VTI1A, Complex: STX12:VTI1A, PubMed

Domains

AA: 29-132, PDBID: 2DNX, Subunit A, Seq Identity:100%, Syntaxin-like protein

AA: 214-266, PDBID: 2NPS, Subunit B, Seq Identity:87%, SNARE domain

UniProt annotation for STX12_HUMAN » Syntaxin-12
FUNCTION: SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity).

SUBUNIT: Interacts with NAPA and SNAP23. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A (By similarity). Associates with the BLOC-1 complex. Interacts with BLOC1S6.

UniProt features for STX12_HUMAN » Syntaxin-12
CHAIN 1 276 Syntaxin-12.
DOMAIN 178 240 t-SNARE coiled-coil homology.
COILED 33 131 Potential.
Amino Acid Sequence for STX12_HUMAN » Syntaxin-12
MSYGPLDMYR NPGPSGPQLR DFSSIIQTCS GNIQRISQAT AQIKNLMSQL GTKQDSSKLQ ENLQQLQHST NQLAKETNEL LKELGSLPLP LSTSEQRQQR LQKERLMNDF SAALNNFQAV QRRVSEKEKE SIARARAGSR LSAEERQREE QLVSFDSHEE WNQMQSQEDE VAITEQDLEL IKERETAIRQ LEADILDVNQ IFKDLAMMIH DQGDLIDSIE ANVESSEVHV ERATEQLQRA AYYQKKSRKK MCILVLVLSV IILILGLIIW LVYKTK