STOM_HUMAN » Erythrocyte band 7 integral membrane protein

STOM_HUMAN » Erythrocyte band 7 integral membrane protein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
STOM_HUMAN » Erythrocyte band 7 integral membrane protein » Protein 7.2b;Stomatin;
Hydrophobic Thickness 34.0 ± 1.0 Å
Tilt Angle 43 ± 7°
ΔGtransfer -29.0 kcal/mol
ΔGfold -19.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 29-58 (29-62)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 55-228, PDBID: 4FVF, Subunit A, Seq Identity:95%, SPFH domain / Band 7 family

UniProt annotation for STOM_HUMAN » Erythrocyte band 7 integral membrane protein
FUNCTION: Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity.
UniProt features for STOM_HUMAN » Erythrocyte band 7 integral membrane protein
CHAIN 1 288 Erythrocyte band 7 integral membrane protein.

REGION 265 273 Required for homooligomerization.

REGION 267 269 Required for lipid raft association.

REGION 273 287 Interaction with LANCL1.

Amino Acid Sequence for STOM_HUMAN » Erythrocyte band 7 integral membrane protein
MAEKRHTRDS EAQRLPDSFK DSPSKGLGPC GWILVAFSFL FTVITFPISI WMCIKIIKEY ERAIIFRLGR ILQGGAKGPG LFFILPCTDS FIKVDMRTIS FDIPPQEILT KDSVTISVDG VVYYRVQNAT LAVANITNAD SATRLLAQTT LRNVLGTKNL SQILSDREEI AHNMQSTLDD ATDAWGIKVE RVEIKDVKLP VQLQRAMAAE AEASREARAK VIAAEGEMNA SRALKEASMV ITESPAALQL RYLQTLTTIA AEKNSTIVFP LPIDMLQGII GAKHSHLG