STML3_HUMAN » Stomatin-like protein 3

STML3_HUMAN » Stomatin-like protein 3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
STML3_HUMAN » Stomatin-like protein 3 » SLP-3;
Hydrophobic Thickness 31.2 ± 3.8 Å
Tilt Angle 48 ± 0°
ΔGtransfer -30.3 kcal/mol
ΔGfold -20.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 26-58 (26-60)
Pathways none
PDB none
OPM none
Complexes none
Interactions

A4, Complex: STML3:A4, PubMed

Domains

AA: 52-225, PDBID: 4FVF, Subunit A, Seq Identity:65%, SPFH domain / Band 7 family

UniProt annotation for STML3_HUMAN » Stomatin-like protein 3
FUNCTION: Required for the function of many mechanoreceptors. Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins. Potentiates PIEZO1 and PIEZO2 function by increasing their sensitivity to mechanical stimulations.

SUBUNIT: Homodimer. Interacts with PIEZO1 and PIEZO2.

UniProt features for STML3_HUMAN » Stomatin-like protein 3
CHAIN 1 291 Stomatin-like protein 3.
Amino Acid Sequence for STML3_HUMAN » Stomatin-like protein 3
MDSRVSSPEK QDKENFVGVN NKRLGVCGWI LFSLSFLLVI ITFPISIWMC LKIIKEYERA VVFRLGRIQA DKAKGPGLIL VLPCIDVFVK VDLRTVTCNI PPQEILTRDS VTTQVDGVVY YRIYSAVSAV ANVNDVHQAT FLLAQTTLRN VLGTQTLSQI LAGREEIAHS IQTLLDDATE LWGIRVARVE IKDVRIPVQL QRSMAAEAEA TREARAKVLA AEGEMNASKS LKSASMVLAE SPIALQLRYL QTLSTVATEK NSTIVFPLPM NILEGIGGVS YDNHKKLPNK A