STAB2_HUMAN » Stabilin-2

STAB2_HUMAN » Stabilin-2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
STAB2_HUMAN » Stabilin-2 » FAS1 EGF-like and X-link domain-containing adhesion molecule 2;Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2;FEEL-2; Hyaluronan receptor for endocytosis;
Hydrophobic Thickness 34.8 ± 3.2 Å
Tilt Angle 7 ± 5°
ΔGtransfer -24.4 kcal/mol
ΔGfold -21.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 2460-2483 (2457-2488)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 243-275, PDBID: 1YO8, Subunit A, Seq Identity:41%, EGF domain

AA: 382-507, PDBID: 1NYO, Subunit A, Seq Identity:22%, Fasciclin domain

AA: 526-654, PDBID: 1W7D, Subunit A, Seq Identity:27%, Fasciclin domain

AA: 957-993, PDBID: 1YO8, Subunit A, Seq Identity:39%, EGF domain

AA: 1005-1129, PDBID: 1X3B, Subunit A, Seq Identity:23%, Fasciclin domain

AA: 1148-1267, PDBID: 1NYO, Subunit A, Seq Identity:26%, Fasciclin domain

AA: 1475-1511, PDBID: 2MGP, Subunit A, Seq Identity:33%, EGF domain

AA: 1517-1553, PDBID: 1YO8, Subunit A, Seq Identity:36%, EGF domain

AA: 1559-1595, PDBID: 2MGP, Subunit A, Seq Identity:35%, EGF domain

AA: 1608-1726, PDBID: 2MXA, Subunit A, Seq Identity:29%, Fasciclin domain

AA: 1751-1883, PDBID: 1W7D, Subunit A, Seq Identity:30%, Fasciclin domain

AA: 2086-2121, PDBID: 1YO8, Subunit A, Seq Identity:41%, EGF domain

AA: 2127-2164, PDBID: 1YO8, Subunit A, Seq Identity:36%, EGF domain

AA: 2198-2290, PDBID: 1O7B, Subunit T, Seq Identity:49%, Extracellular link domain

AA: 2333-2449, PDBID: 1W7D, Subunit A, Seq Identity:16%, Fasciclin domain

UniProt annotation for STAB2_HUMAN » Stabilin-2
FUNCTION: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS.

SUBUNIT: Interacts with GULP1 and heparin. Also interacts with alpha-M/beta-2 integrin (ITGAM and ITGB2) and thymosin beta 4 (TMSB4X and/or TMSB4Y).

TISSUE SPECIFICITY: Highly expressed in sinusoidal endothelial cells of liver, spleen and lymph nodes. Also expressed in non SEC- cells such as HMDMs (monocyte-derivedmacrophages), HAMs (T-cell leukemia virus type 1-associated myelopathy), and several macrophage cell line.

DOMAIN: Recognizes phosphatidyl serine via its epidermal growth factor-like domains.

UniProt features for STAB2_HUMAN » Stabilin-2
SIGNAL 1 19 Potential.
CHAIN 20 2551 Stabilin-2.
CHAIN 1136 2551 190 kDa form stabilin-2.
DOMAIN 108 148 EGF-like 1.
DOMAIN 156 193 EGF-like 2.
DOMAIN 195 236 EGF-like 3.
DOMAIN 237 276 EGF-like 4.
DOMAIN 322 362 EGF-like 5.
DOMAIN 371 505 FAS1 1.
DOMAIN 515 652 FAS1 2.
DOMAIN 736 776 EGF-like 6.
DOMAIN 826 866 EGF-like 7.
DOMAIN 867 909 EGF-like 8.
DOMAIN 910 952 EGF-like 9.
DOMAIN 953 992 EGF-like 10.
DOMAIN 994 1127 FAS1 3.
DOMAIN 1137 1265 FAS1 4.
DOMAIN 1343 1408 Laminin EGF-like 1.
DOMAIN 1432 1470 EGF-like 11.
DOMAIN 1471 1512 EGF-like 12.
DOMAIN 1513 1554 EGF-like 13.
DOMAIN 1555 1594 EGF-like 14.
DOMAIN 1596 1724 FAS1 5.
DOMAIN 1740 1881 FAS1 6.
DOMAIN 1957 2022 Laminin EGF-like 2.
DOMAIN 2047 2081 EGF-like 15.
DOMAIN 2082 2122 EGF-like 16.
DOMAIN 2123 2165 EGF-like 17.
DOMAIN 2198 2291 Link.
DOMAIN 2311 2446 FAS1 7.
REGION 2504 2514 Interaction with TMSB4X.
DISULFID 112 126 By similarity.
DISULFID 120 136 By similarity.
DISULFID 138 147 By similarity.
DISULFID 160 171 By similarity.
DISULFID 164 181 By similarity.
DISULFID 183 192 By similarity.
DISULFID 199 210 By similarity.
DISULFID 204 222 By similarity.
DISULFID 224 235 By similarity.
DISULFID 241 252 By similarity.
DISULFID 246 262 By similarity.
DISULFID 264 275 By similarity.
DISULFID 326 338 By similarity.
DISULFID 332 348 By similarity.
DISULFID 350 361 By similarity.
DISULFID 740 754 By similarity.
DISULFID 748 764 By similarity.
DISULFID 766 775 By similarity.
DISULFID 830 843 By similarity.
DISULFID 837 852 By similarity.
DISULFID 854 865 By similarity.
DISULFID 871 885 By similarity.
DISULFID 879 895 By similarity.
DISULFID 897 908 By similarity.
DISULFID 914 928 By similarity.
DISULFID 922 938 By similarity.
DISULFID 940 951 By similarity.
DISULFID 957 970 By similarity.
DISULFID 964 980 By similarity.
DISULFID 1348 1362 By similarity.
DISULFID 1356 1372 By similarity.
DISULFID 1374 1383 By similarity.
DISULFID 1395 1406 By similarity.
DISULFID 1399 1416 By similarity.
DISULFID 1418 1427 By similarity.
DISULFID 1436 1446 By similarity.
DISULFID 1440 1456 By similarity.
DISULFID 1458 1469 By similarity.
DISULFID 1475 1488 By similarity.
DISULFID 1482 1498 By similarity.
DISULFID 1500 1511 By similarity.
DISULFID 1517 1530 By similarity.
DISULFID 1524 1540 By similarity.
DISULFID 1542 1553 By similarity.
DISULFID 1559 1572 By similarity.
DISULFID 1566 1582 By similarity.
DISULFID 1962 1976 By similarity.
DISULFID 1970 1986 By similarity.
DISULFID 1988 1997 By similarity.
DISULFID 2009 2020 By similarity.
DISULFID 2014 2030 By similarity.
DISULFID 2032 2041 By similarity.
DISULFID 2051 2061 By similarity.
DISULFID 2055 2067 By similarity.
DISULFID 2069 2080 By similarity.
DISULFID 2086 2099 By similarity.
DISULFID 2093 2108 By similarity.
DISULFID 2110 2121 By similarity.
DISULFID 2127 2141 By similarity.
DISULFID 2135 2151 By similarity.
DISULFID 2153 2164 By similarity.
DISULFID 2220 2289 By similarity.
DISULFID 2244 2265 By similarity.
Amino Acid Sequence for STAB2_HUMAN » Stabilin-2
MMLQHLVIFC LGLVVQNFCS PAETTGQARR CDRKSLLTIR TECRSCALNL GVKCPDGYTM ITSGSVGVRD CRYTFEVRTY SLSLPGCRHI CRKDYLQPRC CPGRWGPDCI ECPGGAGSPC NGRGSCAEGM EGNGTCSCQE GFGGTACETC ADDNLFGPSC SSVCNCVHGV CNSGLDGDGT CECYSAYTGP KCDKPIPECA ALLCPENSRC SPSTEDENKL ECKCLPNYRG DGKYCDPINP CLRKICHPHA HCTYLGPNRH SCTCQEGYRG DGQVCLPVDP CQINFGNCPT KSTVCKYDGP GQSHCECKEH YQNFVPGVGC SMTDICKSDN PCHRNANCTT VAPGRTECIC QKGYVGDGLT CYGNIMERLR ELNTEPRGKW QGRLTSFISL LDKAYAWPLS KLGPFTVLLP TDKGLKGFNV NELLVDNKAA QYFVKLHIIA GQMNIEYMNN TDMFYTLTGK SGEIFNSDKD NQIKLKLHGG KKKVKIIQGD IIASNGLLHI LDRAMDKLEP TFESNNEQTI MTMLQPRYSK FRSLLEETNL GHALDEDGVG GPYTIFVPNN EALNNMKDGT LDYLLSPEGS RKLLELVRYH IVPFTQLEVA TLISTPHIRS MANQLIQFNT TDNGQILAND VAMEEIEITA KNGRIYTLTG VLIPPSIVPI LPHRCDETKR EMKLGTCVSC SLVYWSRCPA NSEPTALFTH RCVYSGRFGS LKSGCARYCN ATVKIPKCCK GFYGPDCNQC PGGFSNPCSG NGQCADSLGG NGTCICEEGF QGSQCQFCSD PNKYGPRCNK KCLCVHGTCN NRIDSDGACL TGTCRDGSAG RLCDKQTSAC GPYVQFCHIH ATCEYSNGTA SCICKAGYEG DGTLCSEMDP CTGLTPGGCS RNAECIKTGT GTHTCVCQQG WTGNGRDCSE INNCLLPSAG GCHDNASCLY VGPGQNECEC KKGFRGNGID CEPITSCLEQ TGKCHPLASC QSTSSGVWSC VCQEGYEGDG FLCYGNAAVE LSFLSEAAIF NRWINNASLQ PTLSATSNLT VLVPSQQATE DMDQDEKSFW LSQSNIPALI KYHMLLGTYR VADLQTLSSS DMLATSLQGN FLHLAKVDGN ITIEGASIVD GDNAATNGVI HIINKVLVPQ RRLTGSLPNL LMRLEQMPDY SIFRGYIIQY NLANAIEAAD AYTVFAPNNN AIENYIREKK VLSLEEDVLR YHVVLEEKLL KNDLHNGMHR ETMLGFSYFL SFFLHNDQLY VNEAPINYTN VATDKGVIHG LGKVLEIQKN RCDNNDTTII RGRCRTCSSE LTCPFGTKSL GNEKRRCIYT SYFMGRRTLF IGCQPKCVRT VITRECCAGF FGPQCQPCPG NAQNVCFGNG ICLDGVNGTG VCECGEGFSG TACETCTEGK YGIHCDQACS CVHGRCNQGP LGDGSCDCDV GWRGVHCDNA TTEDNCNGTC HTSANCLTNS DGTASCKCAA GFQGNGTICT AINACEISNG GCSAKADCKR TTPGRRVCTC KAGYTGDGIV CLEINPCLEN HGGCDKNAEC TQTGPNQAAC NCLPAYTGDG KVCTLINVCL TKNGGCSEFA ICNHTGQVER TCTCKPNYIG DGFTCRGSIY QELPKNPKTS QYFFQLQEHF VKDLVGPGPF TVFAPLSAAF DEEARVKDWD KYGLMPQVLR YHVVACHQLL LENLKLISNA TSLQGEPIVI SVSQSTVYIN NKAKIISSDI ISTNGIVHII DKLLSPKNLL ITPKDNSGRI LQNLTTLATN NGYIKFSNLI QDSGLLSVIT DPIHTPVTLF WPTDQALHAL PAEQQDFLFN QDNKDKLKEY LKFHVIRDAK VLAVDLPTST AWKTLQGSEL SVKCGAGRDI GDLFLNGQTC RIVQRELLFD LGVAYGIDCL LIDPTLGGRC DTFTTFDASG ECGSCVNTPS CPRWSKPKGV KQKCLYNLPF KRNLEGCRER CSLVIQIPRC CKGYFGRDCQ ACPGGPDAPC NNRGVCLDQY SATGECKCNT GFNGTACEMC WPGRFGPDCL PCGCSDHGQC DDGITGSGQC LCETGWTGPS CDTQAVLPAV CTPPCSAHAT CKENNTCECN LDYEGDGITC TVVDFCKQDN GGCAKVARCS QKGTKVSCSC QKGYKGDGHS CTEIDPCADG LNGGCHEHAT CKMTGPGKHK CECKSHYVGD GLNCEPEQLP IDRCLQDNGQ CHADAKCVDL HFQDTTVGVF HLRSPLGQYK LTFDKAREAC ANEAATMATY NQLSYAQKAK YHLCSAGWLE TGRVAYPTAF ASQNCGSGVV GIVDYGPRPN KSEMWDVFCY RMKDVNCTCK VGYVGDGFSC SGNLLQVLMS FPSLTNFLTE VLAYSNSSAR GRAFLEHLTD LSIRGTLFVP QNSGLGENET LSGRDIEHHL ANVSMFFYND LVNGTTLQTR LGSKLLITAS QDPLQPTETR FVDGRAILQW DIFASNGIIH VISRPLKAPP APVTLTHTGL GAGIFFAIIL VTGAVALAAY SYFRINRRTI GFQHFESEED INVAALGKQQ PENISNPLYE STTSAPPEPS YDPFTDSEER QLEGNDPLRT L