STAB1_HUMAN » Stabilin-1

STAB1_HUMAN » Stabilin-1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
STAB1_HUMAN » Stabilin-1 » Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1;FEEL-1; MS-1 antigen;
Hydrophobic Thickness 32.4 ± 2.2 Å
Tilt Angle 3 ± 1°
ΔGtransfer -33.0 kcal/mol
ΔGfold -13.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 2475-2499 (2475-2502)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 375-493, PDBID: 1NYO, Subunit A, Seq Identity:19%, Fasciclin domain

AA: 517-643, PDBID: 1W7D, Subunit A, Seq Identity:31%, Fasciclin domain

AA: 951-987, PDBID: 1YO8, Subunit A, Seq Identity:34%, EGF domain

AA: 999-1120, PDBID: 1X3B, Subunit A, Seq Identity:24%, Fasciclin domain

AA: 1139-1253, PDBID: 1W7D, Subunit A, Seq Identity:23%, Fasciclin domain

AA: 1459-1495, PDBID: 1YO8, Subunit A, Seq Identity:36%, EGF domain

AA: 1501-1538, PDBID: 1YO8, Subunit A, Seq Identity:38%, EGF domain

AA: 1596-1710, PDBID: 1W7D, Subunit A, Seq Identity:25%, Fasciclin domain

AA: 1735-1866, PDBID: 1W7D, Subunit A, Seq Identity:30%, Fasciclin domain

AA: 2095-2130, PDBID: 1YO8, Subunit A, Seq Identity:39%, EGF domain

AA: 2208-2300, PDBID: 1O7B, Subunit T, Seq Identity:51%, Extracellular link domain

UniProt annotation for STAB1_HUMAN » Stabilin-1
FUNCTION: Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system.

SUBUNIT: Interacts with CHID1.

TISSUE SPECIFICITY: High levels found in spleen, lymph node, liver and placenta. Also expressed in endothelial cells.

UniProt features for STAB1_HUMAN » Stabilin-1
SIGNAL 1 25 Potential.
CHAIN 26 2570 Stabilin-1.
DOMAIN 110 148 EGF-like 1.
DOMAIN 156 193 EGF-like 2.
DOMAIN 195 229 EGF-like 3.
DOMAIN 232 271 EGF-like 4.
DOMAIN 356 494 FAS1 1.
DOMAIN 506 641 FAS1 2.
DOMAIN 728 768 EGF-like 5.
DOMAIN 818 858 EGF-like 6.
DOMAIN 861 903 EGF-like 7.
DOMAIN 904 946 EGF-like 8.
DOMAIN 947 986 EGF-like 9.
DOMAIN 988 1118 FAS1 3.
DOMAIN 1128 1253 FAS1 4.
DOMAIN 1327 1392 Laminin EGF-like 1.
DOMAIN 1416 1454 EGF-like 10.
DOMAIN 1455 1496 EGF-like 11.
DOMAIN 1497 1539 EGF-like 12.
DOMAIN 1540 1582 EGF-like 13.
DOMAIN 1582 1708 FAS1 5.
DOMAIN 1724 1864 FAS1 6.
DOMAIN 1966 2031 Laminin EGF-like 2.
DOMAIN 2056 2090 EGF-like 14.
DOMAIN 2091 2131 EGF-like 15.
DOMAIN 2132 2174 EGF-like 16.
DOMAIN 2206 2301 Link.
DOMAIN 2322 2459 FAS1 7.
DISULFID 112 126 By similarity.
DISULFID 120 136 By similarity.
DISULFID 138 147 By similarity.
DISULFID 160 171 By similarity.
DISULFID 164 181 By similarity.
DISULFID 183 192 By similarity.
DISULFID 199 210 By similarity.
DISULFID 204 217 By similarity.
DISULFID 236 247 By similarity.
DISULFID 241 257 By similarity.
DISULFID 259 270 By similarity.
DISULFID 732 746 By similarity.
DISULFID 740 756 By similarity.
DISULFID 758 767 By similarity.
DISULFID 822 837 By similarity.
DISULFID 831 846 By similarity.
DISULFID 865 879 By similarity.
DISULFID 873 889 By similarity.
DISULFID 891 902 By similarity.
DISULFID 908 922 By similarity.
DISULFID 916 932 By similarity.
DISULFID 934 945 By similarity.
DISULFID 951 964 By similarity.
DISULFID 958 974 By similarity.
DISULFID 1332 1346 By similarity.
DISULFID 1340 1356 By similarity.
DISULFID 1358 1367 By similarity.
DISULFID 1379 1390 By similarity.
DISULFID 1383 1400 By similarity.
DISULFID 1402 1411 By similarity.
DISULFID 1420 1430 By similarity.
DISULFID 1424 1440 By similarity.
DISULFID 1442 1453 By similarity.
DISULFID 1459 1472 By similarity.
DISULFID 1466 1482 By similarity.
DISULFID 1484 1495 By similarity.
DISULFID 1501 1514 By similarity.
DISULFID 1508 1524 By similarity.
DISULFID 1526 1538 By similarity.
DISULFID 1544 1557 By similarity.
DISULFID 1551 1567 By similarity.
DISULFID 1569 1581 By similarity.
DISULFID 1971 1985 By similarity.
DISULFID 1979 1995 By similarity.
DISULFID 1997 2006 By similarity.
DISULFID 2018 2029 By similarity.
DISULFID 2023 2039 By similarity.
DISULFID 2041 2050 By similarity.
DISULFID 2060 2070 By similarity.
DISULFID 2064 2076 By similarity.
DISULFID 2078 2089 By similarity.
DISULFID 2095 2108 By similarity.
DISULFID 2102 2117 By similarity.
DISULFID 2119 2130 By similarity.
DISULFID 2136 2150 By similarity.
DISULFID 2144 2160 By similarity.
DISULFID 2162 2173 By similarity.
DISULFID 2230 2299 By similarity.
DISULFID 2254 2275 By similarity.
Amino Acid Sequence for STAB1_HUMAN » Stabilin-1
MAGPRGLLPL CLLAFCLAGF SFVRGQVLFK GCDVKTTFVT HVPCTSCAAI KKQTCPSGWL RELPDQITQD CRYEVQLGGS MVSMSGCRRK CRKQVVQKAC CPGYWGSRCH ECPGGAETPC NGHGTCLDGM DRNGTCVCQE NFRGSACQEC QDPNRFGPDC QSVCSCVHGV CNHGPRGDGS CLCFAGYTGP HCDQELPVCQ ELRCPQNTQC SAEAPSCRCL PGYTQQGSEC RAPNPCWPSP CSLLAQCSVS PKGQAQCHCP ENYHGDGMVC LPKDPCTDNL GGCPSNSTLC VYQKPGQAFC TCRPGLVSIN SNASAGCFAF CSPFSCDRSA TCQVTADGKT SCVCRESEVG DGRACYGHLL HEVQKATQTG RVFLQLRVAV AMMDQGCREI LTTAGPFTVL VPSVSSFSSR TMNASLAQQL CRQHIIAGQH ILEDTRTQQT RRWWTLAGQE ITVTFNQFTK YSYKYKDQPQ QTFNIYKANN IAANGVFHVV TGLRWQAPSG TPGDPKRTIG QILASTEAFS RFETILENCG LPSILDGPGP FTVFAPSNEA VDSLRDGRLI YLFTAGLSKL QELVRYHIYN HGQLTVEKLI SKGRILTMAN QVLAVNISEE GRILLGPEGV PLQRVDVMAA NGVIHMLDGI LLPPTILPIL PKHCSEEQHK IVAGSCVDCQ ALNTSTCPPN SVKLDIFPKE CVYIHDPTGL NVLKKGCASY CNQTIMEQGC CKGFFGPDCT QCPGGFSNPC YGKGNCSDGI QGNGACLCFP DYKGIACHIC SNPNKHGEQC QEDCGCVHGL CDNRPGSGGV CQQGTCAPGF SGRFCNESMG DCGPTGLAQH CHLHARCVSQ EGVARCRCLD GFEGDGFSCT PSNPCSHPDR GGCSENAECV PGSLGTHHCT CHKGWSGDGR VCVAIDECEL DVRGGCHTDA LCSYVGPGQS RCTCKLGFAG DGYQCSPIDP CRAGNGGCHG LATCRAVGGG QRVCTCPPGF GGDGFSCYGD IFRELEANAH FSIFYQWLKS AGITLPADRR VTALVPSEAA VRQLSPEDRA FWLQPRTLPN LVRAHFLQGA LFEEELARLG GQEVATLNPT TRWEIRNISG RVWVQNASVD VADLLATNGV LHILSQVLLP PRGDVPGGQG LLQQLDLVPA FSLFRELLQH HGLVPQIEAA TAYTIFVPTN RSLEAQGNSS HLDADTVRHH VVLGEALSME TLRKGGHRNS LLGPAHWIVF YNHSGQPEVN HVPLEGPMLE APGRSLIGLS GVLTVGSSRC LHSHAEALRE KCVNCTRRFR CTQGFQLQDT PRKSCVYRSG FSFSRGCSYT CAKKIQVPDC CPGFFGTLCE PCPGGLGGVC SGHGQCQDRF LGSGECHCHE GFHGTACEVC ELGRYGPNCT GVCDCAHGLC QEGLQGDGSC VCNVGWQGLR CDQKITSPQC PRKCDPNANC VQDSAGASTC ACAAGYSGNG IFCSEVDPCA HGHGGCSPHA NCTKVAPGQR TCTCQDGYMG DGELCQEINS CLIHHGGCHI HAECIPTGPQ QVSCSCREGY SGDGIRTCEL LDPCSKNNGG CSPYATCKST GDGQRTCTCD TAHTVGDGLT CRARVGLELL RDKHASFFSL RLLEYKELKG DGPFTIFVPH ADLMSNLSQD ELARIRAHRQ LVFRYHVVGC RRLRSEDLLE QGYATALSGH PLRFSEREGS IYLNDFARVV SSDHEAVNGI LHFIDRVLLP PEALHWEPDD APIPRRNVTA AAQGFGYKIF SGLLKVAGLL PLLREASHRP FTMLWPTDAA FRALPPDRQA WLYHEDHRDK LAAILRGHMI RNVEALASDL PNLGPLRTMH GTPISFSCSR TRPGELMVGE DDARIVQRHL PFEGGLAYGI DQLLEPPGLG ARCDHFETRP LRLNTCSICG LEPPCPEGSQ EQGSPEACWR FYPKFWTSPP LHSLGLRSVW VHPSLWGRPQ GLGRGCHRNC VTTTWKPSCC PGHYGSECQA CPGGPSSPCS DRGVCMDGMS GSGQCLCRSG FAGTACELCA PGAFGPHCQA CRCTVHGRCD EGLGGSGSCF CDEGWTGPRC EVQLELQPVC TPPCAPEAVC RAGNSCECSL GYEGDGRVCT VADLCQDGHG GCSEHANCSQ VGTMVTCTCL PDYEGDGWSC RARNPCTDGH RGGCSEHANC LSTGLNTRRC ECHAGYVGDG LQCLEESEPP VDRCLGQPPP CHSDAMCTDL HFQEKRAGVF HLQATSGPYG LNFSEAEAAC EAQGAVLASF PQLSAAQQLG FHLCLMGWLA NGSTAHPVVF PVADCGNGRV GIVSLGARKN LSERWDAYCF RVQDVACRCR NGFVGDGIST CNGKLLDVLA ATANFSTFYG MLLGYANATQ RGLDFLDFLD DELTYKTLFV PVNEGFVDNM TLSGPDLELH ASNATLLSAN ASQGKLLPAH SGLSLIISDA GPDNSSWAPV APGTVVVSRI IVWDIMAFNG IIHALASPLL APPQPQAVLA PEAPPVAAGV GAVLAAGALL GLVAGALYLR ARGKPMGFGF SAFQAEDDAD DDFSPWQEGT NPTLVSVPNP VFGSDTFCEP FDDSLLEEDF PDTQRILTVK