|SSRD_HUMAN » Translocon-associated protein subunit delta » TRAP-delta; Signal sequence receptor subunit delta;SSR-delta;|
|Hydrophobic Thickness||30.4 ± 3.0 Å|
|Tilt Angle||7 ± 6°|
|Links||UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome, HMDB|
|TM Segments||146-167 (145-169)|
Gene Expression (Reactome)
EGFR, Complex: SSRD:EGFR
LMTK1, Complex: SSRD:LMTK1
|UniProt annotation for SSRD_HUMAN » Translocon-associated protein subunit delta|
|FUNCTION: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. SUBUNIT: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. DISEASE: Congenital disorder of glycosylation 1Y (CDG1Y) OMIM: A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N- glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Note=The disease is caused by mutations affecting the gene represented in this entry.|
|UniProt features for SSRD_HUMAN » Translocon-associated protein subunit delta|
SIGNAL 1 23 Potential. |
CHAIN 24 173 Translocon-associated protein subunit delta.
DISULFID 26 57 By similarity.
CROSSLNK 73 73 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin).
|Amino Acid Sequence for SSRD_HUMAN » Translocon-associated protein subunit delta|
|MAAMASLGAL ALLLLSSLSR CSAEACLEPQ ITPSYYTTSD AVISTETVFI VEISLTCKNR VQNMALYADV GGKQFPVTRG QDVGRYQVSW SLDHKSAHAG TYEVRFFDEE SYSLLRKAQR NNEDISIIPP LFTVSVDHRG TWNGPWVSTE VLAAAIGLVI YYLAFSAKSH IQA|