SSRD_HUMAN » Translocon-associated protein subunit delta

SSRD_HUMAN » Translocon-associated protein subunit delta
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
SSRD_HUMAN » Translocon-associated protein subunit delta » TRAP-delta; Signal sequence receptor subunit delta;SSR-delta;
Hydrophobic Thickness 30.4 ± 3.0 Å
Tilt Angle 7 ± 6°
ΔGtransfer -17.1 kcal/mol
ΔGfold -9.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome, HMDB
Topology Out
TM Segments 146-167 (145-169)
Pathways

Gene Expression (Reactome)

Protein processing in endoplasmic reticulum (KEGG)

PDB none
OPM none
Complexes none
Interactions

1A66, Complex: 1A66:SSRD, PubMed

CADH2, Complex: CADH2:SSRD, PubMed

ECE1, Complex: SSRD:ECE1, PubMed

EGFR, Complex: SSRD:EGFR

LMTK1, Complex: SSRD:LMTK1

NEP, Complex: NEP:SSRD, PubMed

OST48, Complex: OST48:SSRD, PubMed

SSRA, Complex: SSRA:SSRD, PubMed

SSRB, Complex: SSRA:SSRD:SSRG:SSRB, PubMed

TNR14, Complex: TNR14:SSRD, PubMed

TNR1A, Complex: SSRD:TNR1A, PubMed

TNR1B, Complex: SSRD:TNR1B, PubMed

Domains

AA: 11-172, Translocon-associated protein, delta subunit precursor (TRAP-delta)

UniProt annotation for SSRD_HUMAN » Translocon-associated protein subunit delta
FUNCTION: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

SUBUNIT: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.

DISEASE: Congenital disorder of glycosylation 1Y (CDG1Y) OMIM: A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N- glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Note=The disease is caused by mutations affecting the gene represented in this entry.

UniProt features for SSRD_HUMAN » Translocon-associated protein subunit delta
SIGNAL 1 23 Potential.
CHAIN 24 173 Translocon-associated protein subunit delta.
DISULFID 26 57 By similarity.
CROSSLNK 73 73 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin).
Amino Acid Sequence for SSRD_HUMAN » Translocon-associated protein subunit delta
MAAMASLGAL ALLLLSSLSR CSAEACLEPQ ITPSYYTTSD AVISTETVFI VEISLTCKNR VQNMALYADV GGKQFPVTRG QDVGRYQVSW SLDHKSAHAG TYEVRFFDEE SYSLLRKAQR NNEDISIIPP LFTVSVDHRG TWNGPWVSTE VLAAAIGLVI YYLAFSAKSH IQA