SSRB_HUMAN » Translocon-associated protein subunit beta

SSRB_HUMAN » Translocon-associated protein subunit beta
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
SSRB_HUMAN » Translocon-associated protein subunit beta » TRAP-beta; Signal sequence receptor subunit beta;SSR-beta;
Hydrophobic Thickness 32.0 ± 2.2 Å
Tilt Angle 14 ± 1°
ΔGtransfer -21.8 kcal/mol
ΔGfold -9.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome, HMDB
Topology Out
TM Segments 148-170 (148-173)
Pathways

Gene Expression (Reactome)

Protein processing in endoplasmic reticulum (KEGG)

PDB none
OPM none
Complexes none
Interactions

SC61B, Complex: SSRB:SC61B, PubMed

SSRA, Complex: SSRD:SSRA:SSRG:SSRB, PubMed

SSRD, Complex: SSRA:SSRD:SSRG:SSRB, PubMed

Domains

AA: 3-181, Translocon-associated protein beta (TRAPB)

UniProt annotation for SSRB_HUMAN » Translocon-associated protein subunit beta
FUNCTION: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

SUBUNIT: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with TMEM173/STING.

UniProt features for SSRB_HUMAN » Translocon-associated protein subunit beta
SIGNAL 1 17 By similarity.
CHAIN 18 183 Translocon-associated protein subunit beta.
Amino Acid Sequence for SSRB_HUMAN » Translocon-associated protein subunit beta
MRLLSFVVLA LFAVTQAEEG ARLLASKSLL NRYAVEGRDL TLQYNIYNVG SSAALDVELS DDSFPPEDFG IVSGMLNVKW DRIAPASNVS HTVVLRPLKA GYFNFTSATI TYLAQEDGPV VIGSTSAPGQ GGILAQREFD RRFSPHFLDW AAFGVMTLPS IGIPLLLWYS SKRKYDTPKT KKN