SSRA_HUMAN » Translocon-associated protein subunit alpha

SSRA_HUMAN » Translocon-associated protein subunit alpha
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
SSRA_HUMAN » Translocon-associated protein subunit alpha » TRAP-alpha; Signal sequence receptor subunit alpha;SSR-alpha;
Hydrophobic Thickness 30.8 ± 1.8 Å
Tilt Angle 29 ± 0°
ΔGtransfer -23.4 kcal/mol
ΔGfold -19.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome, HMDB
Topology Out
TM Segments 205-229 (205-235)
Pathways

Gene Expression (Reactome)

Protein processing in endoplasmic reticulum (KEGG)

PDB none
OPM none
Complexes none
Interactions

1B07, Complex: SSRA:1B07, PubMed

1B42, Complex: 1B42:SSRA, PubMed

CALX, Complex: SSRA:CALX, PubMed

EDEM1, Complex: SSRA:EDEM1, PubMed

EGFR, Complex: SSRA:EGFR, PubMed

ERBB2, Complex: SSRA:ERBB2, PubMed

ERBB3, Complex: SSRA:ERBB3, PubMed

FKBP8, Complex: FKBP8:SSRA, PubMed

SC61B, Complex: SC61B:SSRA, PubMed

SSRB, Complex: SSRD:SSRA:SSRG:SSRB, PubMed

SSRD, Complex: SSRA:SSRD, PubMed

Domains

AA: 6-285, Translocon-associated protein (TRAP), alpha subunit

UniProt annotation for SSRA_HUMAN » Translocon-associated protein subunit alpha
FUNCTION: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.

SUBUNIT: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.

DOMAIN: Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.

MISCELLANEOUS: Seems to bind calcium.

UniProt features for SSRA_HUMAN » Translocon-associated protein subunit alpha
SIGNAL 1 18
CHAIN 19 286 Translocon-associated protein subunit alpha.
Amino Acid Sequence for SSRA_HUMAN » Translocon-associated protein subunit alpha
MRLLPRLLLL LLLVFPATVL FRGGPRGLLA VAQDLTEDEE TVEDSIIEDE DDEAEVEEDE PTDLVEDKEE EDVSGEPEAS PSADTTILFV KGEDFPANNI VKFLVGFTNK GTEDFIVESL DASFRYPQDY QFYIQNFTAL PLNTVVPPQR QATFEYSFIP AEPMGGRPFG LVINLNYKDL NGNVFQDAVF NQTVTVIERE DGLDGETIFM YMFLAGLGLL VIVGLHQLLE SRKRKRPIQK VEMGTSSQND VDMSWIPQET LNQINKASPR RLPRKRAQKR SVGSDE