SSRA_DICDI » Translocon-associated protein subunit alpha

SSRA_DICDI » Translocon-associated protein subunit alpha
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
SSRA_DICDI » Translocon-associated protein subunit alpha » TRAP-alpha; Signal sequence receptor subunit alpha;SSR-alpha;
Hydrophobic Thickness 25.2 ± 2.4 Å
Tilt Angle 1 ± 0°
ΔGtransfer -21.7 kcal/mol
ΔGfold -11.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 162-184 (162-186)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 16-234, Translocon-associated protein (TRAP), alpha subunit

UniProt annotation for SSRA_DICDI » Translocon-associated protein subunit alpha
FUNCTION: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

SUBUNIT: Heterotrimer of TRAP-alpha, TRAP-beta and TRAP-gamma.

DOMAIN: Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.

MISCELLANEOUS: Seems to bind calcium.

UniProt features for SSRA_DICDI » Translocon-associated protein subunit alpha
SIGNAL 1 20 Potential.
CHAIN 21 236 Translocon-associated protein subunit alpha.
Amino Acid Sequence for SSRA_DICDI » Translocon-associated protein subunit alpha
MNKLITLLLA VLMIISCVYS DDVEITDDEV VQATPTSDVS FSYIFPDNQD KNFAAGSVVE VLVGFTNNAD KALNITHIFA SLNHPQDFSV FIQNYTRGDF GIAVEKGHHA TLAYRFVPSE YLEPREFGLL ISLEYQDGAQ NFTQTFFNST INITEKETSF DMDSFFLILL GLGFVGGIGY IVYGKMPKQK KVRTVSKVNK NAVRVETEDE TAEWLSGTSA ASSKVKSVQK VVKKNK