SSRA_ARATH » Translocon-associated protein subunit alpha

SSRA_ARATH » Translocon-associated protein subunit alpha
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
SSRA_ARATH » Translocon-associated protein subunit alpha » TRAP-alpha; Signal sequence receptor subunit alpha;SSR-alpha;
Hydrophobic Thickness 31.6 ± 2.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -23.7 kcal/mol
ΔGfold -17.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 190-210 (188-220)
Pathways none
PDB none
OPM none
Complexes none
Interactions

ATL78, Complex: ATL78:SSRA

CRK33, Complex: CRK33:SSRA

FEI1, Complex: FEI1:SSRA

P24B3, Complex: P24B3:SSRA

SYP21, Complex: SSRA:SYP21, PubMed

Y1661, Complex: Y1661:SSRA

Y2182, Complex: Y2182:SSRA

Y2289, Complex: Y2289:SSRA

Y5659, Complex: Y5659:SSRA

Domains

AA: 1-258, Translocon-associated protein (TRAP), alpha subunit

UniProt annotation for SSRA_ARATH » Translocon-associated protein subunit alpha
FUNCTION: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.

SUBUNIT: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.

DOMAIN: Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.

MISCELLANEOUS: Seems to bind calcium.

UniProt features for SSRA_ARATH » Translocon-associated protein subunit alpha
SIGNAL 1 24 Potential.
CHAIN 25 258 Translocon-associated protein subunit alpha.
Amino Acid Sequence for SSRA_ARATH » Translocon-associated protein subunit alpha
MMNLRVLFLA LLLLASPLLQ VARCQSDAED HSSLVDDVVG ENTDDAVEED DHDLDMNLSS FPGVETVCVF PKNSAKLVPA GEETELLVGL KNEGKTRVGV MGIRASVHLP YDHKLLVQNL TMLRLNNASI PTSLQATFPY IFAVSQYLQP GAFDLVGYII YDVEGKPYQS VFYNGTIEVV ESGGLLSGES VFLLTLGIGL LLLLGLWAYS QVQRLTKKTK KVSKVEVGTR STEASLDEWL EGTTLAKTSS GKTKNKKN