SSH4_YEAST » Protein SSH4

SSH4_YEAST » Protein SSH4
Magnify SSH4_YEAST » Protein SSH4Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Vacuolar membrane
Topologyvacuole lumenal side
cytoplasmic side
SSH4_YEAST » Protein SSH4 » Multicopy suppressor of leflunomide protein 4;Suppressor of SHR3 null mutation protein 4;
Hydrophobic Thickness 33.6 ± 3.0 Å
Tilt Angle 34 ± 0°
ΔGtransfer -30.2 kcal/mol
ΔGfold -30.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 45-71 (38-72)
Pathways none
PDB none
OPM none
Complexes none
Interactions

SC6B1, Complex: SC6B1:SSH4

Domains

AA: 230-344, PDBID: 2YYO, Subunit A, Seq Identity:24%, SPRY domain

UniProt annotation for SSH4_YEAST » Protein SSH4
FUNCTION: Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane. Confers leflunomide resistance when overexpressed.

MISCELLANEOUS: Present with 450 molecules/cell in log phase SD medium.

UniProt features for SSH4_YEAST » Protein SSH4
CHAIN 1 579 Protein SSH4.
DOMAIN 166 364 B30.2/SPRY.
Amino Acid Sequence for SSH4_YEAST » Protein SSH4
MYVTFNEALD SSFGNLESPN HDFKVGDPNM VPTPPMDSDS AAISLAFLIS LSITFAILML ILVVIAAYVT FCGDDESEYD EENALGTRTS GTLHSLFGKK HSGILLDSSF ASPGGFDDEI VLQERELEEL PKMSAYEVEL YIRAKEFQMM SPPMVKDFGT YLDSDDQQFI KDRGIQSYFL LPSINDNIDE YGNFLPSFIV QDKLDIQFSK FNKSSSTVMN YPLPHNRKDA VYFEVKIFRH IQKSNSIFSI GLTTVPYPYF RVPGMAKYSI AYESTGKLRI NNPFTASTLL PKLEEGDTVG FGYRYKTGTI FITHNGKKLM DVTQNIGIDL FIGIGAFNAA YTRTYTRDGL LEDPDNVSFR EALSEGKDIE VAKDLQRVHD PHDESDEMTS DEVELHVNLG QVGFVFIEAN VKKYAFGSVY GQIGIPPAYN GTEIKKDTIL QKGEELPPRY ADTDNFFGSM KVKEGSSSRI TAQTSKPLWS VGTYERISSN FDRENNVYHD SLETDDNNTD NNVNNNDENA GCNENSPLLE DDGNKRPENS NTPREVSDGA INKNPRNKST KKRQRNRGKS SKKKNRSRK