SRPRB_HUMAN » Signal recognition particle receptor subunit beta

SRPRB_HUMAN » Signal recognition particle receptor subunit beta
Magnify SRPRB_HUMAN » Signal recognition particle receptor subunit betaEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
SRPRB_HUMAN » Signal recognition particle receptor subunit beta » SR-beta; Protein APMCF1;
Hydrophobic Thickness 30.8 ± 3.0 Å
Tilt Angle 12 ± 8°
ΔGtransfer -26.6 kcal/mol
ΔGfold -23.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 36-57 (35-64)
Pathways

Gene Expression (Reactome)

Protein export (KEGG)

PDB none
OPM none
Complexes none
Interactions

CAH9, Complex: CAH9:SRPRB, PubMed

EGFR, Complex: SRPRB:EGFR

ERLN2, Complex: SRPRB:ERLN2

RRBP1, Complex: RRBP1:SRPRB, PubMed

SCO2, Complex: SRPRB:SCO2

TMED4, Complex: TMED4:SRPRB, PubMed

TNR14, Complex: SRPRB:TNR14, PubMed

UBP19, Complex: SRPRB:UBP19, PubMed

Domains

AA: 62-241, PDBID: 2FH5, Subunit B, Seq Identity:91%, Signal recognition particle receptor beta subunit

UniProt annotation for SRPRB_HUMAN » Signal recognition particle receptor subunit beta
FUNCTION: Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity).

SUBUNIT: Heterodimer with SRPR.

UniProt features for SRPRB_HUMAN » Signal recognition particle receptor subunit beta
CHAIN 1 271 Signal recognition particle receptor subunit beta.
Amino Acid Sequence for SRPRB_HUMAN » Signal recognition particle receptor subunit beta
MASADSRRVA DGGGAGGTFQ PYLDTLRQEL QQTDPTLLSV VVAVLAVLLT LVFWKLIRSR RSSQRAVLLV GLCDSGKTLL FVRLLTGLYR DTQTSITDSC AVYRVNNNRG NSLTLIDLPG HESLRLQFLE RFKSSARAIV FVVDSAAFQR EVKDVAEFLY QVLIDSMGLK NTPSFLIACN KQDIAMAKSA KLIQQQLEKE LNTLRVTRSA APSTLDSSST APAQLGKKGK EFEFSQLPLK VEFLECSAKG GRGDVGSADI QDLEKWLAKI A