SREC_HUMAN » Scavenger receptor class F member 1

SREC_HUMAN » Scavenger receptor class F member 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SREC_HUMAN » Scavenger receptor class F member 1 » Acetyl LDL receptor;Scavenger receptor expressed by endothelial cells 1;SREC-I;
Hydrophobic Thickness 32.0 ± 3.2 Å
Tilt Angle 12 ± 7°
ΔGtransfer -18.8 kcal/mol
ΔGfold -11.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 420-443 (418-443)
Pathways none
PDB none
OPM none
Complexes none
Interactions

SREC2, Complex: SREC:SREC2, PubMed

Domains

AA: 103-131, PDBID: 4OVE, Subunit A, Seq Identity:34%, Laminin EGF domain

UniProt annotation for SREC_HUMAN » Scavenger receptor class F member 1
FUNCTION: Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity).

SUBUNIT: Heterophilic interaction with SREC2 via its extracellular domain. The heterophilic interaction is suppressed by the presence of ligand such as Ac-LDL. Interacts with AVIL (By similarity).

TISSUE SPECIFICITY: Endothelial cells.

UniProt features for SREC_HUMAN » Scavenger receptor class F member 1
SIGNAL 1 19 Potential.
CHAIN 20 830 Scavenger receptor class F member 1.
DOMAIN 53 87 EGF-like 1.
DOMAIN 95 130 EGF-like 2.
DOMAIN 155 191 EGF-like 3.
DOMAIN 215 249 EGF-like 4.
DOMAIN 302 339 EGF-like 5.
DOMAIN 351 382 EGF-like 6.
DISULFID 57 69 By similarity.
DISULFID 63 75 By similarity.
DISULFID 77 86 By similarity.
DISULFID 99 111 By similarity.
DISULFID 105 118 By similarity.
DISULFID 120 129 By similarity.
DISULFID 159 172 By similarity.
DISULFID 165 179 By similarity.
DISULFID 181 190 By similarity.
DISULFID 219 230 By similarity.
DISULFID 225 237 By similarity.
DISULFID 239 248 By similarity.
DISULFID 306 319 By similarity.
DISULFID 313 326 By similarity.
DISULFID 329 338 By similarity.
DISULFID 355 363 By similarity.
DISULFID 358 370 By similarity.
DISULFID 372 381 By similarity.
Amino Acid Sequence for SREC_HUMAN » Scavenger receptor class F member 1
MGLGLLLPLL LLWTRGTQGS ELDPKGQHVC VASSPSAELQ CCAGWRQKDQ ECTIPICEGP DACQKDEVCV KPGLCRCKPG FFGAHCSSRC PGQYWGPDCR ESCPCHPHGQ CEPATGACQC QADRWGARCE FPCACGPHGR CDPATGVCHC EPGWWSSTCR RPCQCNTAAA RCEQATGACV CKPGWWGRRC SFRCNCHGSP CEQDSGRCAC RPGWWGPECQ QQCECVRGRC SAASGECTCP PGFRGARCEL PCPAGSHGVQ CAHSCGRCKH NEPCSPDTGS CESCEPGWNG TQCQQPCLPG TFGESCEQQC PHCRHGEACE PDTGHCQRCD PGWLGPRCED PCPTGTFGED CGSTCPTCVQ GSCDTVTGDC VCSAGYWGPS CNASCPAGFH GNNCSVPCEC PEGLCHPVSG SCQPGSGSRD TALIVGSLVP LLLLFLGLAC CACCCWAPRS DLKDRPARDG ATVSRMKLQV WGTLTSLGST LPCRSLSSHK LPWVTVSHHD PEVPFNHSFI EPPSAGWATD DSFSSDPESG EADEVPAYCV PPQEGMVPVA QAGSSEASLA AGAFPPPEDA STPFAIPRTS SLARAKRPSV SFAEGTKFAP QSRRSSGELS SPLRKPKRLS RGAQSGPEGR EAEESTGPDE AEAPESFPAA ASPGDSATGH RRPPLGSRTV AEHVEAIEGS VQESSGPVTT IYMLAGKPRG SEGPVRSVFR HFGSFQKGQA EAKVKRAIPK PPRQALNRKK GSPGLASGSV GQSPNSAPKA GLPGATGPMA VRPEEAVRGL GAGTESSRRA QEPVSGCGSP EQDPQKQAEE ERQEEPEYEN VVPISRPPEP