SRCRM_HUMAN » Scavenger receptor cysteine-rich domain-containing protein SCART1

SRCRM_HUMAN » Scavenger receptor cysteine-rich domain-containing protein SCART1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SRCRM_HUMAN » Scavenger receptor cysteine-rich domain-containing protein SCART1 »
Hydrophobic Thickness 38.8 ± 3.2 Å
Tilt Angle 7 ± 4°
ΔGtransfer -51.9 kcal/mol
ΔGfold -18.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 899-926 (896-926)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 32-128, PDBID: 5A2E, Subunit A, Seq Identity:40%, Scavenger receptor cysteine-rich domain

AA: 138-227, PDBID: 5A2E, Subunit A, Seq Identity:30%, Scavenger receptor cysteine-rich domain

AA: 235-326, PDBID: 5A2E, Subunit A, Seq Identity:42%, Scavenger receptor cysteine-rich domain

AA: 331-428, PDBID: 5A2E, Subunit A, Seq Identity:42%, Scavenger receptor cysteine-rich domain

AA: 437-534, PDBID: 5A2E, Subunit A, Seq Identity:45%, Scavenger receptor cysteine-rich domain

AA: 565-656, PDBID: 1BY2, Subunit A, Seq Identity:45%, Scavenger receptor cysteine-rich domain

AA: 664-721, PDBID: 2JOP, Subunit A, Seq Identity:22%, Scavenger receptor cysteine-rich domain

AA: 789-886, PDBID: 1BY2, Subunit A, Seq Identity:56%, Scavenger receptor cysteine-rich domain

UniProt annotation for SRCRM_HUMAN » Scavenger receptor cysteine-rich domain-containing protein SCART1
FUNCTION: May play a role in the immune system, perhaps as a co- receptor on alphabeta and gammadelta T-cells.

TISSUE SPECIFICITY: Mainly expressed by CD4(+) and CD8(+) T lymphocytes. Also highly expressed in small intestine and colon. Expressed (at protein level) in small intestine, stomach, gall bladder, and placental villi.

UniProt features for SRCRM_HUMAN » Scavenger receptor cysteine-rich domain-containing protein SCART1
SIGNAL 1 19 Potential.
CHAIN 20 1027 Putative scavenger receptor cysteine-rich domain-containing protein LOC619207.
DOMAIN 28 128 SRCR 1.
DOMAIN 135 227 SRCR 2.
DOMAIN 232 326 SRCR 3.
DOMAIN 328 428 SRCR 4.
DOMAIN 434 534 SRCR 5.
DOMAIN 555 656 SRCR 6.
DOMAIN 661 761 SRCR 7.
DOMAIN 786 886 SRCR 8.
DISULFID 53 117 By similarity.
DISULFID 66 127 By similarity.
DISULFID 97 107 By similarity.
DISULFID 160 216 By similarity.
DISULFID 171 226 By similarity.
DISULFID 196 206 By similarity.
DISULFID 253 315 By similarity.
DISULFID 266 325 By similarity.
DISULFID 297 307 By similarity.
DISULFID 353 417 By similarity.
DISULFID 366 427 By similarity.
DISULFID 397 407 By similarity.
DISULFID 472 533 By similarity.
DISULFID 503 513 By similarity.
DISULFID 594 655 By similarity.
DISULFID 625 635 By similarity.
DISULFID 824 885 By similarity.
DISULFID 855 865 By similarity.
Amino Acid Sequence for SRCRM_HUMAN » Scavenger receptor cysteine-rich domain-containing protein SCART1
MRAALWTLGL GPLLLNLWAV PIGGPGALRL AYRHSTCDGV VLVRHHGAWG YVCNQEWTLA EASVVCRQLG CGPAVGAPKY VPLPGEMAQP WLHNVSCRGN ESSLWECSLG SWCQSPCPHA WVVVALCSNG TFRELRLVKG RSPCAGLPEI RNVNGVDRLC VLHVEEAMVF CRELGCGPVL QAPRRDVGVV RKYLACRGTE PTIRSCRLDN NFRSGCDLRL DAEVVCSGHT EARLVGGEHP CAGRLEVTWG TVCDAALDLA TAHVVCRELQ CGAVVSTPEG ARFGRGSGPV WTEAFRCAGN ESLLFHCPRG RGSQCGHGHD AGLRCSEFRM VNGSSSCEGR VEFQVQGSWA PLCATHWDIA DATVLCHQLN CGNAVAAPGG GHFGDGDAAI WPDAFHCEGT ESYLWNCPVS TLGAPACAPG NTASAVCSGL AHALRLREGQ SRCDGRVEVS LDGVWGRVLD DAWDLRGAGV VCRQLGCRGA QQAYDAPAPS RGSVQVALSR VRCLGTETRL TQCNVSATLQ EPAGTSRDAG VVCSGEVGTA SPMARRHGIP GALTLSLHRE PQGAAGRGAG ALHGGAWGTV CDDAWDLRDA HVVCRQLGCG RALSALGAAH FGAGAGRIWL DELGCQGHES ALWQCPSAGW GRHDWRHKED AGVFCSESVA LRLRGGTCCC AGWLDVFYNG TWGAMCSNAL KDLSLSIICK QLGCGVWGVG LAGEQALPLC GHRDRLGGQH RVPQAAQLHS VAMPFPPMAP ALLRPSRAGL SEDRPQAAGE PLNCSSWLGC PEEGALRVRG GEDRCSGRVE LWHAGSWGTV CDDGWDLADA EVVCRQLGCG RAVAALGAAA FGPGSGPVWL DEVGCRGSEA SLWGCPAERW GRGDRAHEED AGVRCWEPGP GPPLPAAPFR TFWVVSVVLG SLLGLLLLGL MAFLILPRVT QAMQRGLGRS EVSPGEAIYD VIGEMPPAGL YEEIMEAEAV LQDEEDGSVV KVDTEAAVSG EVSNLLEGQS IRAEGGHSRP VSQGYDEAAF PLEEMTL