SPT25_HUMAN » Spermatogenesis-associated protein 25

SPT25_HUMAN » Spermatogenesis-associated protein 25
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Topology in Membrane
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SPT25_HUMAN » Spermatogenesis-associated protein 25 » Testis-specific gene 23 protein;
Hydrophobic Thickness 26.8 ± 1.6 Å
Tilt Angle 10 ± 6°
ΔGtransfer -16.4 kcal/mol
ΔGfold -7.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Und
TM Segments 149-167 (149-167)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 1-227, Spermatogenesis-associated protein 25

UniProt annotation for SPT25_HUMAN » Spermatogenesis-associated protein 25
FUNCTION: May play a role in spermatogenesis.

TISSUE SPECIFICITY: Expressed predominantly in testis (at protein level). Expression is lower in patients with obstructive azoospermia than in fertile controls and is not detected in patients with non-obstructive azoospermia.

DEVELOPMENTAL STAGE: 60-fold stronger expression found in adult than fetal testis. Detected in spermatocytes and round spermatids of the seminiferous tubule.

UniProt features for SPT25_HUMAN » Spermatogenesis-associated protein 25
CHAIN 1 227 Spermatogenesis-associated protein 25.
Amino Acid Sequence for SPT25_HUMAN » Spermatogenesis-associated protein 25
MSYFRTPQTH PGPLPSGQGG AASPGLSLGL CSPVEPVVVA SGGTGPLSQK AEQVAPAAQA WGPALAMPQA RGCPGGTSWE TLRKEYSRNC HKFPHVRQLE SLGWDNGYSR SRAPDLGGPS RPRPLMLCGL SPRVLPVPSE AVGKEASSQP DICILTLAMM IAGIPTVPVP GVREEDLIWA AQAFMMAHPE PEGAVEGARW EQAHAHTASG KMPLVRSKRG QPPGSCL