SPIT2_HUMAN » Kunitz-type protease inhibitor 2

SPIT2_HUMAN » Kunitz-type protease inhibitor 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SPIT2_HUMAN » Kunitz-type protease inhibitor 2 » Hepatocyte growth factor activator inhibitor type 2;HAI-2; Placental bikunin;
Hydrophobic Thickness 34.8 ± 3.8 Å
Tilt Angle 20 ± 5°
ΔGtransfer -30.5 kcal/mol
ΔGfold -23.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 196-221 (196-226)
Pathways none
PDB 4u32 (X=34-88)
OPM none
Complexes none
Interactions

A4, Complex: SPIT2:A4, PubMed

Domains

AA: 37-89, PDBID: 4U32, Subunit X, Seq Identity:100%, Kunitz/Bovine pancreatic trypsin inhibitor domain

AA: 132-184, PDBID: 1YC0, Subunit I, Seq Identity:55%, Kunitz/Bovine pancreatic trypsin inhibitor domain

UniProt annotation for SPIT2_HUMAN » Kunitz-type protease inhibitor 2
FUNCTION: Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.

TISSUE SPECIFICITY: Expressed in placenta, kidney, pancreas, prostate, testis, thymus, and trachea.

DOMAIN: This inhibitor contains two inhibitory domains.

DISEASE: Diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies (DIAR3) OMIM: A disease characterized by life-threatening secretory diarrhea, severe metabolic acidosis and hyponatremia. Hyponatremia is secondary to extraordinarily high fecal sodium loss, with low or normal excretion of urinary sodium, in the absence of infectious, autoimmune and endocrine causes. Note=The disease is caused by mutations affecting the gene represented in this entry.

UniProt features for SPIT2_HUMAN » Kunitz-type protease inhibitor 2
SIGNAL 1 27
CHAIN 28 252 Kunitz-type protease inhibitor 2.
DOMAIN 38 88 BPTI/Kunitz inhibitor 1.
DOMAIN 133 183 BPTI/Kunitz inhibitor 2.
SITE 48 49 Reactive bond (By similarity).
SITE 143 144 Reactive bond (By similarity).
DISULFID 38 88 By similarity.
DISULFID 47 71 By similarity.
DISULFID 63 84 By similarity.
DISULFID 133 183 By similarity.
DISULFID 142 166 By similarity.
DISULFID 158 179 By similarity.
Amino Acid Sequence for SPIT2_HUMAN » Kunitz-type protease inhibitor 2
MAQLCGLRRS RAFLALLGSL LLSGVLAADR ERSIHDFCLV SKVVGRCRAS MPRWWYNVTD GSCQLFVYGG CDGNSNNYLT KEECLKKCAT VTENATGDLA TSRNAADSSV PSAPRRQDSE DHSSDMFNYE EYCTANAVTG PCRASFPRWY FDVERNSCNN FIYGGCRGNK NSYRSEEACM LRCFRQQENP PLPLGSKVVV LAGLFVMVLI LFLGASMVYL IRVARRNQER ALRTVWSSGD DKEQLVKNTY VL