SORC3_HUMAN » VPS10 domain-containing receptor SorCS3

SORC3_HUMAN » VPS10 domain-containing receptor SorCS3
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Topology in Golgi apparatus membrane
TopologyGolgi lumenal side
cytoplasmic side
SORC3_HUMAN » VPS10 domain-containing receptor SorCS3 »
Hydrophobic Thickness 30.6 ± 1.6 Å
Tilt Angle 20 ± 0°
ΔGtransfer -28.1 kcal/mol
ΔGfold -22.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1126-1147 (1123-1149)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 228-658, PDBID: 3F6K, Subunit A, Seq Identity:24%, Sortilin, neurotensin receptor 3,

AA: 660-816, PDBID: 1WGO, Subunit A, Seq Identity:47%, Sortilin, neurotensin receptor 3, C-terminal

AA: 826-904, PDBID: 1B4R, Subunit A, Seq Identity:29%, PKD domain

UniProt annotation for SORC3_HUMAN » VPS10 domain-containing receptor SorCS3
TISSUE SPECIFICITY: Highly expressed in brain.
UniProt features for SORC3_HUMAN » VPS10 domain-containing receptor SorCS3
SIGNAL 1 33 Potential.
CHAIN 34 1222 VPS10 domain-containing receptor SorCS3.
REPEAT 231 242 BNR 1.
REPEAT 279 290 BNR 2.
REPEAT 320 331 BNR 3.
REPEAT 515 526 BNR 4.
REPEAT 592 603 BNR 5.
REPEAT 634 645 BNR 6.
DOMAIN 827 917 PKD.
Amino Acid Sequence for SORC3_HUMAN » VPS10 domain-containing receptor SorCS3
MEAARTERPA GRPGAPLVRT GLLLLSTWVL AGAEITWDAT GGPGRPAAPA SRPPALSPLS PRAVASQWPE ELASARRAAV LGRRAGPELL PQQGGGRGGE MQVEAGGTSP AGERRGRGIP APAKLGGARR SRRAQPPITQ ERGDAWATAP ADGSRGSRPL AKGSREEVKA PRAGGSAAED LRLPSTSFAL TGDSAHNQAM VHWSGHNSSV ILILTKLYDF NLGSVTESSL WRSTDYGTTY EKLNDKVGLK TVLSYLYVNP TNKRKIMLLS DPEMESSILI SSDEGATYQK YRLTFYIQSL LFHPKQEDWV LAYSLDQKLY SSMDFGRRWQ LMHERITPNR FYWSVAGLDK EADLVHMEVR TTDGYAHYLT CRIQECAETT RSGPFARSID ISSLVVQDEY IFIQVTTSGR ASYYVSYRRE AFAQIKLPKY SLPKDMHIIS TDENQVFAAV QEWNQNDTYN LYISDTRGIY FTLAMENIKS SRGLMGNIII ELYEVAGIKG IFLANKKVDD QVKTYITYNK GRDWRLLQAP DVDLRGSPVH CLLPFCSLHL HLQLSENPYS SGRISSKETA PGLVVATGNI GPELSYTDIG VFISSDGGNT WRQIFDEEYN VWFLDWGGAL VAMKHTPLPV RHLWVSFDEG HSWDKYGFTS VPLFVDGALV EAGMETHIMT VFGHFSLRSE WQLVKVDYKS IFSRHCTKED YQTWHLLNQG EPCVMGERKI FKKRKPGAQC ALGRDHSGSV VSEPCVCANW DFECDYGYER HGESQCVPAF WYNPASPSKD CSLGQSYLNS TGYRRIVSNN CTDGLREKYT AKAQMCPGKA PRGLHVVTTD GRLVAEQGHN ATFIILMEEG DLQRTNIQLD FGDGIAVSYA NFSPIEDGIK HVYKSAGIFQ VTAYAENNLG SDTAVLFLHV VCPVEHVHLR VPFVAIRNKE VNISAVVWPS QLGTLTYFWW FGNSTKPLIT LDSSISFTFL AEGTDTITVQ VAAGNALIQD TKEIAVHEYF QSQLLSFSPN LDYHNPDIPE WRKDIGNVIK RALVKVTSVP EDQILIAVFP GLPTSAELFI LPPKNLTERR KGNEGDLEQI VETLFNALNQ NLVQFELKPG VQVIVYVTQL TLAPLVDSSA GHSSSAMLML LSVVFVGLAV FLIYKFKRKI PWINIYAQVQ HDKEQEMIGS VSQSENAPKI TLSDFTEPEE LLDKELDTRV IGGIATIANS ESTKEIPNCT SV