SORC2_HUMAN » VPS10 domain-containing receptor SorCS2

SORC2_HUMAN » VPS10 domain-containing receptor SorCS2
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Topology in Golgi apparatus membrane
TopologyGolgi lumenal side
cytoplasmic side
SORC2_HUMAN » VPS10 domain-containing receptor SorCS2 »
Hydrophobic Thickness 32.8 ± 2.5 Å
Tilt Angle 9 ± 1°
ΔGtransfer -25.7 kcal/mol
ΔGfold -23.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1081-1103 (1080-1106)
Pathways none
PDB 1wgo (760-869)
OPM none
Complexes none
Interactions

TNR16, Complex: TNR16:SORC2

Domains

AA: 179-611, PDBID: 3F6K, Subunit A, Seq Identity:26%, Sortilin, neurotensin receptor 3,

AA: 613-775, PDBID: 1WGO, Subunit A, Seq Identity:100%, Sortilin, neurotensin receptor 3, C-terminal

AA: 788-863, PDBID: 1WGO, Subunit A, Seq Identity:100%, PKD domain

UniProt annotation for SORC2_HUMAN » VPS10 domain-containing receptor SorCS2
TISSUE SPECIFICITY: Highly expressed in brain and kidney. Detected at low levels in heart, liver, small intestine, skeletal muscle and thymus.
UniProt features for SORC2_HUMAN » VPS10 domain-containing receptor SorCS2
SIGNAL 1 50 Potential.
CHAIN 51 1159 VPS10 domain-containing receptor SorCS2.
REPEAT 182 193 BNR 1.
REPEAT 232 243 BNR 2.
REPEAT 273 284 BNR 3.
REPEAT 468 479 BNR 4.
REPEAT 545 556 BNR 5.
REPEAT 587 598 BNR 6.
DOMAIN 786 876 PKD.
Amino Acid Sequence for SORC2_HUMAN » VPS10 domain-containing receptor SorCS2
MAHRGPSRAS KGPGPTARAP SPGAPPPPRS PRSRPLLLLL LLLGACGAAG RSPEPGRLGP HAQLTRVPRS PPAGRAEPGG GEDRQARGTE PGAPGPSPGP APGPGEDGAP AAGYRRWERA APLAGVASRA QVSLISTSFV LKGDATHNQA MVHWTGENSS VILILTKYYH ADMGKVLESS LWRSSDFGTS YTKLTLQPGV TTVIDNFYIC PTNKRKVILV SSSLSDRDQS LFLSADEGAT FQKQPIPFFV ETLIFHPKEE DKVLAYTKES KLYVSSDLGK KWTLLQERVT KDHVFWSVSG VDADPDLVHV EAQDLGGDFR YVTCAIHNCS EKMLTAPFAG PIDHGSLTVQ DDYIFFKATS ANQTKYYVSY RRNEFVLMKL PKYALPKDLQ IISTDESQVF VAVQEWYQMD TYNLYQSDPR GVRYALVLQD VRSSRQAEES VLIDILEVRG VKGVFLANQK IDGKVMTLIT YNKGRDWDYL RPPSMDMNGK PTNCKPPDCH LHLHLRWADN PYVSGTVHTK DTAPGLIMGA GNLGSQLVEY KEEMYITSDC GHTWRQVFEE EHHILYLDHG GVIVAIKDTS IPLKILKFSV DEGLTWSTHN FTSTSVFVDG LLSEPGDETL VMTVFGHISF RSDWELVKVD FRPSFSRQCG EEDYSSWELS NLQGDRCIMG QQRSFRKRKS TSWCIKGRSF TSALTSRVCE CRDSDFLCDY GFERSPSSES STNKCSANFW FNPLSPPDDC ALGQTYTSSL GYRKVVSNVC EGGVDMQQSQ VQLQCPLTPP RGLQVSIQGE AVAVRPGEDV LFVVRQEQGD VLTTKYQVDL GDGFKAMYVN LTLTGEPIRH RYESPGIYRV SVRAENTAGH DEAVLFVQVN SPLQALYLEV VPVIGLNQEV NLTAVLLPLN PNLTVFYWWI GHSLQPLLSL DNSVTTRFSD TGDVRVTVQA ACGNSVLQDS RVLRVLDQFQ VMPLQFSKEL DAYNPNTPEW REDVGLVVTR LLSKETSVPQ ELLVTVVKPG LPTLADLYVL LPPPRPTRKR SLSSDKRLAA IQQVLNAQKI SFLLRGGVRV LVALRDTGTG AEQLGGGGGY WAVVVLFVIG LFAAGAFILY KFKRKRPGRT VYAQMHNEKE QEMTSPVSHS EDVQGAVQGN HSGVVLSINS REMHSYLVS