SORC1_HUMAN » VPS10 domain-containing receptor SorCS1

SORC1_HUMAN » VPS10 domain-containing receptor SorCS1
Magnify SORC1_HUMAN » VPS10 domain-containing receptor SorCS1Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Golgi apparatus membrane
TopologyGolgi lumenal side
cytoplasmic side
SORC1_HUMAN » VPS10 domain-containing receptor SorCS1 » hSorCS;
Hydrophobic Thickness 30.8 ± 1.8 Å
Tilt Angle 16 ± 0°
ΔGtransfer -27.7 kcal/mol
ΔGfold -21.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1102-1123 (1101-1125)
Pathways none
PDB none
OPM none
Complexes none
Interactions

FURIN, Complex: FURIN:SORC1, PubMed

SORT, Complex: SORT:SORC1, PubMed

Domains

AA: 205-635, PDBID: 3F6K, Subunit A, Seq Identity:24%, Sortilin, neurotensin receptor 3,

AA: 637-792, PDBID: 1WGO, Subunit A, Seq Identity:53%, Sortilin, neurotensin receptor 3, C-terminal

AA: 803-880, PDBID: 1WGO, Subunit A, Seq Identity:34%, PKD domain

UniProt annotation for SORC1_HUMAN » VPS10 domain-containing receptor SorCS1
TISSUE SPECIFICITY: Detected in fetal and infant brain and in fetal retina.
UniProt features for SORC1_HUMAN » VPS10 domain-containing receptor SorCS1
SIGNAL 1 33 Potential.
CHAIN 34 1168 VPS10 domain-containing receptor SorCS1.
REPEAT 208 219 BNR 1.
REPEAT 256 267 BNR 2.
REPEAT 492 503 BNR 3.
REPEAT 569 580 BNR 4.
REPEAT 611 622 BNR 5.
DOMAIN 803 894 PKD.
Amino Acid Sequence for SORC1_HUMAN » VPS10 domain-containing receptor SorCS1
MGKVGAGGGS QARLSALLAG AGLLILCAPG VCGGGSCCPS PHPSSAPRSA STPRGFSHQG RPGRAPATPL PLVVRPLFSV APGDRALSLE RARGTGASMA VAARSGRRRR SGADQEKAER GEGASRSPRG VLRDGGQQEP GTRERDPDKA TRFRMEELRL TSTTFALTGD SAHNQAMVHW SGHNSSVILI LTKLYDYNLG SITESSLWRS TDYGTTYEKL NDKVGLKTIL SYLYVCPTNK RKIMLLTDPE IESSLLISSD EGATYQKYRL NFYIQSLLFH PKQEDWILAY SQDQKLYSSA EFGRRWQLIQ EGVVPNRFYW SVMGSNKEPD LVHLEARTVD GHSHYLTCRM QNCTEANRNQ PFPGYIDPDS LIVQDHYVFV QLTSGGRPHY YVSYRRNAFA QMKLPKYALP KDMHVISTDE NQVFAAVQEW NQNDTYNLYI SDTRGVYFTL ALENVQSSRG PEGNIMIDLY EVAGIKGMFL ANKKIDNQVK TFITYNKGRD WRLLQAPDTD LRGDPVHCLL PYCSLHLHLK VSENPYTSGI IASKDTAPSI IVASGNIGSE LSDTDISMFV SSDAGNTWRQ IFEEEHSVLY LDQGGVLVAM KHTSLPIRHL WLSFDEGRSW SKYSFTSIPL FVDGVLGEPG EETLIMTVFG HFSHRSEWQL VKVDYKSIFD RRCAEEDYRP WQLHSQGEAC IMGAKRIYKK RKSERKCMQG KYAGAMESEP CVCTEADFDC DYGYERHSNG QCLPAFWFNP SSLSKDCSLG QSYLNSTGYR KVVSNNCTDG VREQYTAKPQ KCPGKAPRGL RIVTADGKLT AEQGHNVTLM VQLEEGDVQR TLIQVDFGDG IAVSYVNLSS MEDGIKHVYQ NVGIFRVTVQ VDNSLGSDSA VLYLHVTCPL EHVHLSLPFV TTKNKEVNAT AVLWPSQVGT LTYVWWYGNN TEPLITLEGS ISFRFTSEGM NTITVQVSAG NAILQDTKTI AVYEEFRSLR LSFSPNLDDY NPDIPEWRRD IGRVIKKSLV EATGVPGQHI LVAVLPGLPT TAELFVLPYQ DPAGENKRST DDLEQISELL IHTLNQNSVH FELKPGVRVL VHAAHLTAAP LVDLTPTHSG SAMLMLLSVV FVGLAVFVIY KFKRRVALPS PPSPSTQPGD SSLRLQRARH ATPPSTPKRG SAGAQYAI