SN_HUMAN » Sialoadhesin

SN_HUMAN » Sialoadhesin
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SN_HUMAN » Sialoadhesin » Sialic acid-binding Ig-like lectin 1;Siglec-1;
Hydrophobic Thickness 35.6 ± 2.8 Å
Tilt Angle 24 ± 4°
ΔGtransfer -26.3 kcal/mol
ΔGfold -22.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1639-1665 (1638-1669)
Pathways

Cell adhesion molecules (KEGG)

PDB none
OPM 1url (MOUSE)
Complexes none
Interactions

LEUK, Complex: SN:LEUK, PubMed

MUC1, Complex: SN:MUC1, PubMed

Domains

AA: 24-136, PDBID: 1OD7, Subunit A, Seq Identity:79%, Immunoglobulin V-set domain

AA: 142-228, PDBID: 3EPC, Subunit R, Seq Identity:18%, CD80-like C2-set immunoglobulin domain

AA: 242-323, PDBID: 2ENS, Subunit A, Seq Identity:36%, Immunoglobulin domain

AA: 326-408, PDBID: 2ENS, Subunit A, Seq Identity:29%, Immunoglobulin domain

AA: 418-507, PDBID: 3MTR, Subunit A, Seq Identity:30%, Immunoglobulin I-set domain

AA: 512-594, PDBID: 1E4J, Subunit A, Seq Identity:31%, Immunoglobulin domain

AA: 896-978, PDBID: 2DRU, Subunit A, Seq Identity:27%, Immunoglobulin domain

AA: 992-1083, PDBID: 2CPC, Subunit A, Seq Identity:35%, Immunoglobulin I-set domain

AA: 1086-1168, PDBID: 1E4J, Subunit A, Seq Identity:31%, Immunoglobulin domain

AA: 1262-1342, PDBID: 3AY4, Subunit C, Seq Identity:28%, Immunoglobulin domain

UniProt annotation for SN_HUMAN » Sialoadhesin
FUNCTION: Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis.

TISSUE SPECIFICITY: Expressed by macrophages in various tissues. High levels are found in spleen, lymph node, perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophages in rheumatoid arthritis.

UniProt features for SN_HUMAN » Sialoadhesin
SIGNAL 1 19 By similarity.
CHAIN 20 1709 Sialoadhesin.
DOMAIN 20 136 Ig-like V-type.
DOMAIN 139 233 Ig-like C2-type 1.
DOMAIN 238 320 Ig-like C2-type 2.
DOMAIN 326 405 Ig-like C2-type 3.
DOMAIN 411 507 Ig-like C2-type 4.
DOMAIN 511 593 Ig-like C2-type 5.
DOMAIN 601 705 Ig-like C2-type 6.
DOMAIN 708 785 Ig-like C2-type 7.
DOMAIN 799 894 Ig-like C2-type 8.
DOMAIN 898 977 Ig-like C2-type 9.
DOMAIN 984 1083 Ig-like C2-type 10.
DOMAIN 1085 1165 Ig-like C2-type 11.
DOMAIN 1176 1248 Ig-like C2-type 12.
DOMAIN 1259 1341 Ig-like C2-type 13.
DOMAIN 1350 1442 Ig-like C2-type 14.
DOMAIN 1445 1528 Ig-like C2-type 15.
DOMAIN 1536 1631 Ig-like C2-type 16.
REGION 122 126 Sialic acid binding (By similarity).
DISULFID 36 166 By similarity.
DISULFID 41 98 By similarity.
DISULFID 160 217 By similarity.
DISULFID 262 305 By similarity.
DISULFID 346 390 By similarity.
DISULFID 433 491 By similarity.
DISULFID 531 575 By similarity.
DISULFID 624 689 By similarity.
DISULFID 729 774 By similarity.
DISULFID 817 876 By similarity.
DISULFID 916 960 By similarity.
DISULFID 1005 1067 By similarity.
DISULFID 1107 1149 By similarity.
DISULFID 1193 1241 By similarity.
DISULFID 1281 1324 By similarity.
DISULFID 1367 1425 By similarity.
DISULFID 1465 1511 By similarity.
DISULFID 1554 1613 By similarity.
Amino Acid Sequence for SN_HUMAN » Sialoadhesin
MGFLPKLLLL ASFFPAGQAS WGVSSPQDVQ GVKGSCLLIP CIFSFPADVE VPDGITAIWY YDYSGQRQVV SHSADPKLVE ARFRGRTEFM GNPEHRVCNL LLKDLQPEDS GSYNFRFEIS EVNRWSDVKG TLVTVTEEPR VPTIASPVEL LEGTEVDFNC STPYVCLQEQ VRLQWQGQDP ARSVTFNSQK FEPTGVGHLE TLHMAMSWQD HGRILRCQLS VANHRAQSEI HLQVKYAPKG VKILLSPSGR NILPGELVTL TCQVNSSYPA VSSIKWLKDG VRLQTKTGVL HLPQAAWSDA GVYTCQAENG VGSLVSPPIS LHIFMAEVQV SPAGPILENQ TVTLVCNTPN EAPSDLRYSW YKNHVLLEDA HSHTLRLHLA TRADTGFYFC EVQNVHGSER SGPVSVVVNH PPLTPVLTAF LETQAGLVGI LHCSVVSEPL ATLVLSHGGH ILASTSGDSD HSPRFSGTSG PNSLRLEIRD LEETDSGEYK CSATNSLGNA TSTLDFHANA ARLLISPAAE VVEGQAVTLS CRSGLSPTPD ARFSWYLNGA LLHEGPGSSL LLPAASSTDA GSYHCRARDG HSASGPSSPA VLTVLYPPRQ PTFTTRLDLD AAGAGAGRRG LLLCRVDSDP PARLQLLHKD RVVATSLPSG GGCSTCGGCS PRMKVTKAPN LLRVEIHNPL LEEEGLYLCE ASNALGNAST SATFNGQATV LAIAPSHTLQ EGTEANLTCN VSREAAGSPA NFSWFRNGVL WAQGPLETVT LLPVARTDAA LYACRILTEA GAQLSTPVLL SVLYPPDRPK LSALLDMGQG HMALFICTVD SRPLALLALF HGEHLLATSL GPQVPSHGRF QAKAEANSLK LEVRELGLGD SGSYRCEATN VLGSSNTSLF FQVRGAWVQV SPSPELQEGQ AVVLSCQVHT GVPEGTSYRW YRDGQPLQES TSATLRFAAI TLTQAGAYHC QAQAPGSATT SLAAPISLHV SYAPRHVTLT TLMDTGPGRL GLLLCRVDSD PPAQLRLLHG DRLVASTLQG VGGPEGSSPR LHVAVAPNTL RLEIHGAMLE DEGVYICEAS NTLGQASASA DFDAQAVNVQ VWPGATVREG QLVNLTCLVW TTHPAQLTYT WYQDGQQRLD AHSIPLPNVT VRDATSYRCG VGPPGRAPRL SRPITLDVLY APRNLRLTYL LESHGGQLAL VLCTVDSRPP AQLALSHAGR LLASSTAASV PNTLRLELRG PQPRDEGFYS CSARSPLGQA NTSLELRLEG VRVILAPEAA VPEGAPITVT CADPAAHAPT LYTWYHNGRW LQEGPAASLS FLVATRAHAG AYSCQAQDAQ GTRSSRPAAL QVLYAPQDAV LSSFRDSRAR SMAVIQCTVD SEPPAELALS HDGKVLATSS GVHSLASGTG HVQVARNALR LQVQDVPAGD DTYVCTAQNL LGSISTIGRL QVEGARVVAE PGLDVPEGAA LNLSCRLLGG PGPVGNSTFA WFWNDRRLHA EPVPTLAFTH VARAQAGMYH CLAELPTGAA ASAPVMLRVL YPPKTPTMMV FVEPEGGLRG ILDCRVDSEP LASLTLHLGS RLVASSQPQG APAEPHIHVL ASPNALRVDI EALRPSDQGE YICSASNVLG SASTSTYFGV RALHRLHQFQ QLLWVLGLLV GLLLLLLGLG ACYTWRRRRV CKQSMGENSV EMAFQKETTQ LIDPDAATCE TSTCAPPLG