SNPH_HUMAN » Syntaphilin

SNPH_HUMAN » Syntaphilin
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SNPH_HUMAN » Syntaphilin »
Hydrophobic Thickness 32.8 ± 2.6 Å
Tilt Angle 1 ± 0°
ΔGtransfer -18.9 kcal/mol
ΔGfold -7.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 424-446 (420-449)
Pathways none
PDB none
OPM none
Complexes none
Interactions

STX1A, Complex: SNPH:STX1A, PubMed

STX3, Complex: STX3:SNPH, PubMed

Domains

AA: 18-333, Golgi-localised syntaxin-1-binding clamp

UniProt annotation for SNPH_HUMAN » Syntaphilin
FUNCTION: Inhibits SNARE complex formation by absorbing free syntaxin-1.

SUBUNIT: Binds to syntaxin-1.

TISSUE SPECIFICITY: Brain specific. Found in synapses.

UniProt features for SNPH_HUMAN » Syntaphilin
CHAIN 1 494 Syntaphilin.
COILED 79 161 Potential.
Amino Acid Sequence for SNPH_HUMAN » Syntaphilin
MAMSLPGSRR TSAGSRRRTS PPVSVRDAYG TSSLSSSSNS GSYKGSDSSP TPRRSMKYTL CSDNHGIKPP TPEQYLTPLQ QKEVCIRHLK ARLKDTQDRL QDRDTEIDDL KTQLSRMQED WIEEECHRVE AQLALKEARK EIKQLKQVID TVKNNLIDKD KGLQKYFVDI NIQNKKLETL LHSMEVAQNG MAKEDGTGES AGGSPARSLT RSSTYTKLSD PAVCGDRQPG DPSSGSAEDG ADSGFAAADD TLSRTDALEA SSLLSSGVDC GTEETSLHSS FGLGPRFPAS NTYEKLLCGM EAGVQASCMQ ERAIQTDFVQ YQPDLDTILE KVTQAQVCGT DPESGDRCPE LDAHPSGPRD PNSAVVVTVG DELEAPEPIT RGPTPQRPGA NPNPGQSVSV VCPMEEEEEA AVAEKEPKSY WSRHYIVDLL AVVVPAVPTV AWLCRSQRRQ GQPIYNISSL LRGCCTVALH SIRRISCRSL SQPSPSPAGG GSQL