SNL1_YEAST » HSP70 co-chaperone SNL1

SNL1_YEAST » HSP70 co-chaperone SNL1
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
SNL1_YEAST » HSP70 co-chaperone SNL1 » Suppressor of NUP116-C lethal;
Hydrophobic Thickness 31.6 ± 3.0 Å
Tilt Angle 1 ± 0°
ΔGtransfer -22.1 kcal/mol
ΔGfold -18.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 16-36 (5-37)
Pathways

Protein processing in endoplasmic reticulum (KEGG)

PDB none
OPM none
Complexes none
Interactions

EMP24, Complex: EMP24:SNL1, PubMed

FET3, Complex: SNL1:FET3, PubMed

GPI8, Complex: SNL1:GPI8, PubMed

GSF2, Complex: SNL1:GSF2, PubMed

MNN10, Complex: RS6B:RL20B:RS14A:RS4B:RS17B:RL4B:RLA0:RS8B:RL13B:RL6B:RL27B:RL8B:RL2B:RL30:RS13:RS24B:RS3A2:RL14B:RL35B:EF1A:G3P3:FKS1:HSP71:HSP75:HSP76:TBA1:TBB:MNN10:SEC7:YL173:SNL1, PubMed

MSMO, Complex: MSMO:SNL1, PubMed

OST1, Complex: OST1:SNL1, PubMed

OSTB, Complex: OSTB:SNL1, PubMed

PMP2, Complex: SNL1:PMP2, PubMed

SAC1, Complex: SAC1:SNL1, PubMed

YHO0, Complex: SNL1:YHO0, PubMed

YL173, Complex: YL173:SNL1, PubMed

Domains

AA: 74-158, PDBID: 4HWC, Subunit F, Seq Identity:23%, BAG domain

UniProt annotation for SNL1_YEAST » HSP70 co-chaperone SNL1
FUNCTION: Stimulator of ATPase activity of molecular chaperones of the HSP70 family (principally of the SSA class). Stimulation is important for HSP70-substrate complex dissociation after folding of newly synthesized or refolded proteins. SNL1 is probably involved in nuclear pore biogenesis and in particular the folding or refolding of misfolded NUP116, GLE2 and NIC96.

SUBUNIT: Interacts with the HSP70 family members SSA1, SSA4, and SSB1. These interactions are strongly reduced by ADP and ATP.

MISCELLANEOUS: Present with 3346 molecules/cell in log phase SD medium.

UniProt features for SNL1_YEAST » HSP70 co-chaperone SNL1
CHAIN 1 159 HSP70 co-chaperone SNL1.
DOMAIN 73 159 BAG.
Amino Acid Sequence for SNL1_YEAST » HSP70 co-chaperone SNL1
MSHNAMEHWK SKLSKTSTST YVLLAVIAVV FLVTIRRPNG SKGKSSKKRA SKKNKKGKNQ FEKAPVPLTL EEQIDNVSLR YGNELEGRSK DLINRFDVED EKDIYERNYC NEMLLKLLIE LDSIDLINVD ESLRRPLKEK RKGVIKEIQA MLKSLDSLK