SLIK6_HUMAN » SLIT and NTRK-like protein 6

SLIK6_HUMAN » SLIT and NTRK-like protein 6
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SLIK6_HUMAN » SLIT and NTRK-like protein 6 »
Hydrophobic Thickness 39.2 ± 2.2 Å
Tilt Angle 0 ± 2°
ΔGtransfer -58.8 kcal/mol
ΔGfold -27.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 604-633 (604-639)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 141-195, PDBID: 4Y61, Subunit B, Seq Identity:72%, Leucine rich repeat

AA: 364-423, PDBID: 2FT3, Subunit F, Seq Identity:43%, Leucine rich repeat

AA: 411-470, PDBID: 1GWB, Subunit B, Seq Identity:40%, Leucine rich repeat

AA: 459-518, PDBID: 4V2E, Subunit A, Seq Identity:39%, Leucine rich repeat

UniProt annotation for SLIK6_HUMAN » SLIT and NTRK-like protein 6
FUNCTION: Regulator of neurite outgrowth required for normal hearing and vision.

TISSUE SPECIFICITY: In adult brain, highly expressed in putamen with no expression in cerebral cortex. Expressed in adult and fetal lung and fetal liver. Also expressed at high levels in some brain tumors including medulloblastomas and primitive neuroectodermal tumors.

DISEASE: Deafness and myopia (DFNMYP) OMIM: An autosomal recessive disorder characterized by prelingual sensorineural hearing loss associated with high myopia. Note=The disease is caused by mutations affecting the gene represented in this entry.

UniProt features for SLIK6_HUMAN » SLIT and NTRK-like protein 6
SIGNAL 1 26 Potential.
CHAIN 27 841 SLIT and NTRK-like protein 6.
DOMAIN 27 67 LRRNT 1.
REPEAT 89 110 LRR 1.
REPEAT 113 134 LRR 2.
REPEAT 137 158 LRR 3.
REPEAT 161 182 LRR 4.
REPEAT 184 205 LRR 5.
DOMAIN 218 269 LRRCT 1.
DOMAIN 320 361 LRRNT 2.
REPEAT 364 385 LRR 6.
REPEAT 388 409 LRR 7.
REPEAT 412 433 LRR 8.
REPEAT 436 457 LRR 9.
REPEAT 460 481 LRR 10.
REPEAT 483 504 LRR 11.
DOMAIN 517 568 LRRCT 2.
Amino Acid Sequence for SLIK6_HUMAN » SLIT and NTRK-like protein 6
MKLWIHLFYS SLLACISLHS QTPVLSSRGS CDSLCNCEEK DGTMLINCEA KGIKMVSEIS VPPSRPFQLS LLNNGLTMLH TNDFSGLTNA ISIHLGFNNI ADIEIGAFNG LGLLKQLHIN HNSLEILKED TFHGLENLEF LQADNNFITV IEPSAFSKLN RLKVLILNDN AIESLPPNIF RFVPLTHLDL RGNQLQTLPY VGFLEHIGRI LDLQLEDNKW ACNCDLLQLK TWLENMPPQS IIGDVVCNSP PFFKGSILSR LKKESICPTP PVYEEHEDPS GSLHLAATSS INDSRMSTKT TSILKLPTKA PGLIPYITKP STQLPGPYCP IPCNCKVLSP SGLLIHCQER NIESLSDLRP PPQNPRKLIL AGNIIHSLMK SDLVEYFTLE MLHLGNNRIE VLEEGSFMNL TRLQKLYLNG NHLTKLSKGM FLGLHNLEYL YLEYNAIKEI LPGTFNPMPK LKVLYLNNNL LQVLPPHIFS GVPLTKVNLK TNQFTHLPVS NILDDLDLLT QIDLEDNPWD CSCDLVGLQQ WIQKLSKNTV TDDILCTSPG HLDKKELKAL NSEILCPGLV NNPSMPTQTS YLMVTTPATT TNTADTILRS LTDAVPLSVL ILGLLIMFIT IVFCAAGIVV LVLHRRRRYK KKQVDEQMRD NSPVHLQYSM YGHKTTHHTT ERPSASLYEQ HMVSPMVHVY RSPSFGPKHL EEEEERNEKE GSDAKHLQRS LLEQENHSPL TGSNMKYKTT NQSTEFLSFQ DASSLYRNIL EKERELQQLG ITEYLRKNIA QLQPDMEAHY PGAHEELKLM ETLMYSRPRK VLVEQTKNEY FELKANLHAE PDYLEVLEQQ T